Research
Publications, projects, and academic contributions
Publications & Research
321 total publications spanning multiple research domains in biostatistics, clinical trials, and medical research.
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Use the search box below to filter publications by title, author, journal, topic, or year.
2024
A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with Early Alzheimer's Disease
Galasko, Douglas, Farlow, Martin R, Lucey, Brendan P, Honig, Lawrence S, Elbert, Donald, Bateman, Randall, Momper, Jeremiah, **Thomas, Ronald G**, Rissman, Robert A, Pa, Judy, & others | Alzheimer's Research \& Therapy | (2024)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
Cumulative blast impulse is predictive for changes in chronic neurobehavioral symptoms following low level blast exposure during military training
McEvoy, Cory, Crabtree, Adam, Case, John, Means, Gary E, Muench, Peter, **Thomas, Ronald G**, Ivory, Rebecca A, Mihalik, Jason, & Meabon, James S | Military medicine | (2024)
Summary: Investigating health impacts in military populations and combat environments
Topics: Biostatistics R Military health
Links: 📄 Article • 📋 Open Access PDF
Increased [18F] Fluorodeoxyglucose Uptake in the Left Pallidum in Military Veterans with Blast-Related Mild Traumatic Brain Injury: Potential as an Imaging Biomarker and Mediation with Executive Dysfunction and Cognitive Impairment
Terry, Garth, Pagulayan, Kathleen F, Muzi, Mark, Mayer, Cynthia, Murray, Daniel R, Schindler, Abigail G, Richards, Todd L, McEvoy, Cory, Crabtree, Adam, McNamara, Chris, & others | Journal of Neurotrauma | (2024)
Summary: Investigating health impacts in military populations and combat environments
Topics: Biostatistics R Traumatic brain injury Military health Neuroimaging Biomarkers Cognitive decline
Links: 📄 Article
2023
A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial
Reiman, Eric M, Pruzin, Jeremy J, Rios-Romenets, Silvia, Brown, Chris, Giraldo, Margarita, Acosta-Baena, Natalia, Tobon, Carlos, Hu, Nan, Chen, Yinghua, Ghisays, Valentina, & others | Alzheimer's \& Dementia | (2023)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Prevention trials
Links: 📄 Article • 📋 Open Access PDF
A randomized controlled clinical trial of prazosin for alcohol use disorder in active duty soldiers: Predictive effects of elevated cardiovascular parameters
Raskind, Murray A, Williams, Tammy, Holmes, Hollie, Hart, Kim, Crews, Laura, Poupore, Eileen L, **Thomas, Ronald G**, Darnell, Jolee, Daniels, Colin, Goke, Kevin, & others | Alcoholism: Clinical and Experimental Research | (2023)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials
Links: 📄 Article • 📋 Open Access PDF
FDG-PET as a Clinical Diagnostic Biomarker for Repetitive Blast Mild Traumatic Brain Injury
Terry, Garth, Pagulayan, Kati, Muzi, Mark, Mayer, Cynthia, Murray, Daniel, Schindler, Abigail, Richards, Todd, McEvoy, Cory, Crabtree, Adam, McNamara, Chris, & others | NEUROPSYCHOPHARMACOLOGY | (2023)
Summary: Investigating health impacts in military populations and combat environments
Topics: Biostatistics R Traumatic brain injury Neuroimaging Biomarkers
Links: 📄 Article
Impact of reference region on longitudinal florbetapir PET SUVR changes from the API ADAD Colombia Trial
Ghisays, Valentina, Lopera, Francisco, Su, Yi, Malek-Ahmadi, Michael H, Chen, Yinghua, Protas, Hillary D, Luo, Ji, Hu, Nan, Clayton, David, Schiffman, Courtney, & others | Alzheimer's \& Dementia | (2023)
Summary: Developing biomarkers and imaging techniques for disease detection
Topics: Biostatistics R Neuroimaging Longitudinal studies
Links: 📄 Article
Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults
Keil, Samantha A, Schindler, Abigail G, Wang, Marie X, Piantino, Juan, Silbert, Lisa C, Elliott, Jonathan E, Werhane, Madeleine L, **Thomas, Ronald G**, Willis, Sherry, Lim, Miranda M, & others | JAMA Network Open | (2023)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Sleep disorders Cognitive decline Longitudinal studies
Links: 📄 Article
Pontine pathology mediates common symptoms of blast-induced chronic mild traumatic brain injury
Meabon, James S, Schindler, Abigail G, Murray, Daniel R, Colasurdo, Elizabeth A, Sikkema, Carl L, Rodriguez, Joshua W, Omer, Mohamed, Cline, Marcella M, Logsdon, Aric F, Cross, Donna J, & others | medRxiv | (2023)
Summary: Investigating health impacts in military populations and combat environments
Topics: Biostatistics R Traumatic brain injury
Links: 📄 Article • 📋 Open Access PDF
Prognostic value of plasma biomarkers in a clinical trial of mild-to-moderate Alzheimer's Disease
Qiu, Yuqi, Messer, Karen, Jacobs, Diane M, Salmon, David P, Kaplita, Stephen, Wellington, Cheryl L, Stukas, Sophie K, Askew, Brianna, Brewer, James B, Brody, Mark, & others | Alzheimer's \& Dementia | (2023)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Biomarkers
Links: 📄 Article
The relative contribution of COVID-19 infection versus COVID-19 related occupational stressors to insomnia in healthcare workers
Hendrickson, Rebecca C, McCall, Catherine A, Rosser, Aaron F, Pagulayan, Kathleen F, Chang, Bernard P, Sano, Ellen D, **Thomas, Ronald G**, & Raskind, Murray A | Sleep medicine: X | (2023)
Summary: Addressing public health challenges during global health crises
Topics: Biostatistics R COVID-19 Sleep disorders
Links: 📄 Article • 📋 Open Access PDF
2022
Markers of Cerebrovascular Injury, Inflammation, and Plasma Lipids Are Associated with Alzheimer's Disease Cerebrospinal Fluid Biomarkers in Cognitively Normal Persons
Jansson, Deidre, Wang, Marie, **Thomas, Ronald G.**, Erickson, Michelle A., Peskind, Elaine R., Li, Ge, & Iliff, Jeffrey | Journal of Alzheimer's Disease | (2022)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: biomarkers blood-brain barrier cerebrospinal fluid hdl ldl ptau tau Alzheimer's disease Biomarkers Cognitive decline
Links: 📄 Article
Sex differences in cognitive resilience in preclinical autosomal-dominant Alzheimer's disease carriers and non-carriers: baseline findings from the API ADAD Colombia Trial
Vila-Castelar, Clara, Tariot, Pierre N, Sink, Kaycee M, Clayton, David, Langbaum, Jessica B, **Thomas, Ronald G**, Chen, Yinghua, Su, Yi, Chen, Kewei, Hu, Nan, & others | Alzheimer's \& Dementia | (2022)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article
T2 Protect AD: Achieving a rapid recruitment timeline in a multisite clinical trial for individuals with mild to moderate Alzheimer's disease
Shadyab, Aladdin H, LaCroix, Andrea Z, Matthews, Genevieve, Bennett, Daniel, Shadyab, Alexandre A, Tan, Donna, **Thomas, Ronald G**, Mason, Jennifer, Lopez, Alex, Askew, Brianna, & others | Alzheimer's \& Dementia: Translational Research \& Clinical Interventions | (2022)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article • 📋 Open Access PDF
The impact of the COVID-19 pandemic on mental health, occupational functioning, and professional retention among health care workers and first responders
Hendrickson, Rebecca C & Slevin, Rois\'\i | Journal of general internal medicine | (2022)
Summary: Addressing public health challenges during global health crises
Topics: Biostatistics R COVID-19
Links: 📄 Article • 📋 Open Access PDF
2021
A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease
Salloway, Stephen, Farlow, Martin, McDade, Eric, Clifford, David B, Wang, Guoqiao, Llibre-Guerra, Jorge J, Hitchcock, Janice M, Mills, Susan L, Santacruz, Anna M, Aschenbrenner, Andrew J, Hassenstab, Jason, Benzinger, Tammie L S, Gordon, Brian A, Fagan, Anne M, Coalier, Kelley A, Cruchaga, Carlos, Goate, Alison A, Perrin, Richard J, Xiong, Chengjie, ..., S\'a | Nature Medicine | (2021)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Amyloid and tau pathology associations with personality traits, neuropsychiatric symptoms, and cognitive lifestyle in the preclinical phases of sporadic and autosomal dominant Alzheimer’s disease
Binette, Alexa Pichet, Vachon-Presseau, Etienne, Morris, John, Bateman, Randall, Benzinger, Tammie, Collins, D Louis, Poirier, Judes, Breitner, John CS, Villeneuve, Sylvia, Allegri, Ricardo, & others | Biological psychiatry | (2021)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Optimizing aggregated N-of-1 trial designs for predictive biomarker validation: statistical methods and theoretical findings
Hendrickson, Rebecca C, **Thomas, Ronald G**, Schork, Nicholas J, & Raskind, Murray A | Creating Evidence from Real World Patient Digital Data | (2021)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Biomarkers Statistical methods
Links: 📄 Article • 📋 Open Access PDF
Power and sample size for random coefficient regression models in randomized experiments with monotone missing data
Hu, Nan, Mackey, Howard, & **Thomas, Ronald** | Biometrical Journal | (2021)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Clinical trials
Links: 📄 Article • 📋 Open Access PDF
Rasagiline effects on glucose metabolism, cognition, and tau in Alzheimer's dementia
Matthews, Dawn C, Ritter, Aaron, **Thomas, Ronald G**, Andrews, Randolph D, Lukic, Ana S, Revta, Carolyn, Kinney, Jefferson W, Tousi, Babak, Leverenz, James B, Fillit, Howard, & others | Alzheimer's \& Dementia: Translational Research \& Clinical Interventions | (2021)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Recruitment of a multi-site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: the EXERT trial
Shadyab, Aladdin & others | Alzheimer's \& Dementia | (2021)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials Cognitive decline
The Impact of the COVID-19 Pandemic on Mental Health, Occupational Functioning, and Professional Retention Among Health Care Workers and First Responders
Hendrickson, Rebecca C & Slevin, Rois\'\i | Journal of general internal medicine | (2021)
Summary: Addressing public health challenges during global health crises
Topics: Biostatistics R COVID-19
2020
Baseline demographic, clinical, and cognitive characteristics of the Alzheimer's Prevention Initiative (API) Autosomal-Dominant Alzheimer's Disease Colombia Trial
Rios-Romenets, Silvia, Lopera, Francisco, Sink, Kaycee M, Hu, Nan, Lian, Qinshu, Guthrie, Heather, Smith, Jillian, Cho, William, Mackey, Howard, Langbaum, Jessica B, & others | Alzheimer's \& Dementia | (2020)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline Prevention trials
Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with MCI: The ADAS-Cog-Exec
Jacobs, Diane M, **Thomas, Ronald G**, Salmon, David P, Jin, Shelia, Feldman, Howard H, Cotman, Carl W, Baker, Laura D, Alzheimer's Disease Cooperative Study EXERT Study Group, & Alzheimer's Disease Neuroimaging Initiative | Alzheimer's \& Dementia: Translational Research \& Clinical Interventions | (2020)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Cognitive decline
Optimizing aggregated n-of-1 trial designs for predictive biomarker validation: statistical methods and theoretical findings
Hendrickson, Rebecca C, **Thomas, Ronald G**, Schork, Nicholas J, & Raskind, Murray A | Frontiers in Digital Health | (2020)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Biomarkers Statistical methods
Links: 📄 Article
PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer's disease
Ghisays, Valentina, Lopera, Francisco, Goradia, Dhruman D, Protas, Hillary D, Malek-Ahmadi, Michael H, Chen, Yinghua, Devadas, Vivek, Luo, Ji, Lee, Wendy, Brown, Christopher T, & others | 2020 Alzheimer's Association International Conference | (2020)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Neuroimaging
Sex differences in neurodegeneration and memory performance in preclinical autosomal dominant Alzheimer’s disease: Baseline findings from the API ADAD trial: Intersections of sex/gender and race/ethnicity in cognitive aging and Alzheimer’s disease trajectories
Vila-Castelar, Clara, Tariot, Pierre N, Sink, Kaycee M, Clayton, David, Langbaum, Jessica B, **Thomas, Ronald G**, Chen, Yinghua, Su, Yi, Hu, Nan, Giraldo-Chica, Margarita, & others | Alzheimer's \& Dementia | (2020)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
The Alzheimer’s Prevention Initiative Composite Cognitive Test: a practical measure for tracking cognitive decline in preclinical Alzheimer’s disease
Langbaum, Jessica B, Ellison, Noel N, Caputo, Angelika, **Thomas, Ronald G**, Langlois, Carolyn, Riviere, Marie-Emmanuelle, Graf, Ana, Lopez Lopez, Cristina, Reiman, Eric M, Tariot, Pierre N, & others | Alzheimer's Research \& Therapy | (2020)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline Prevention trials
The Effects of Rasagiline on Glucose Metabolism and Cognition and Their Relationship to Tau Burden in a Double-Blind, Placebo-Controlled Phase Ii Clinical Trial of Participants with Alzheimer's Dementia
Matthews, Dawn, Ritter, Aaron, **Thomas, Ronald G**, Andrews, Randolph D, Lukic, Ana S, Revta, Carolyn, Tousi, Babak, Leverenz, James B, Fillit, Howard, Zhong, Kate, & others | Placebo-Controlled Phase Ii Clinical Trial of Participants with Alzheimer's Dementia (2/21/2020) | (2020)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
2019
A randomized clinical trial to evaluate home-based assessment of people over 75 years old
Sano, Mary, Zhu, Carolyn W, Kaye, Jeffrey, Mundt, James C, Hayes, Tamara L, Ferris, Steven, **Thomas, Ronald G**, Sun, Chung-Kai, Jiang, Yanxin, Donohue, Michael C, & others | Alzheimer's \& Dementia | (2019)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials
Links: 📄 Article
F4-04-01: TRIAL DESIGN, DATA SHARING RISK MITIGATION, AND BASELINE CLINICAL AND COGNITIVE DATA FROM THE API AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE COLOMBIA TRIAL
Tariot, Pierre N, Lopera, Francisco, Sink, Kaycee, Hu, Nan, Guthrie, Heather, Smith, Jillian, Cho, William, Langbaum, Jessica B, **Thomas, Ronald G**, Giraldo, Margarita, & others | Alzheimer's \& Dementia | (2019)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article • 📋 Open Access PDF
F4-04-02: AGE-RELATED CHANGES IN BASELINE COGNITIVE MEASURES IN UNIMPAIRED PSEN1 E280A MUTATION CARRIERS AND NON-CARRIERS IN THE API AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE COLOMBIA TRIAL
Acosta-Baena, Natalia, Rios-Romenets, Silvia, Munoz, Claudia, Bocanegra, Yamile, Henao, Eliana, Giraldo, Margarita, Tobon, Carlos, Sink, Kaycee, Hu, Nan, Guthrie, Heather, & others | Alzheimer's \& Dementia | (2019)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article • 📋 Open Access PDF
F4-04-03: RELATIONSHIPS BETWEEN BASELINE BRAIN IMAGING BIOMARKER MEASUREMENTS AND AGE IN THE API AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE COLOMBIA TRIAL
Su, Yi, Rios-Romenets, Silvia, Tariot, Pierre N, Sink, Kaycee, Clayton, David, Hu, Nan, Guthrie, Heather, Smith, Jillian, Cho, William, Langbaum, Jessica B, & others | Alzheimer's \& Dementia | (2019)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Neuroimaging Biomarkers
F4-04-04: ASSOCIATION BETWEEN CEREBRAL AMYLOIDOSIS AND WORSE COGNITIVE PERFORMANCE IN PRECLINICAL AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE: BASELINE FINDINGS FROM THE API COLOMBIA AUTOSOMAL DOMINANT AD TRIAL
Quiroz, Yakeel T, Tariot, Pierre N, Sink, Kaycee, Clayton, David, Langbaum, Jessica B, **Thomas, Ronald G**, Giraldo, Margarita, Tobon, Carlos, Acosta-Baena, Natalia, Luna, Ernesto, & others | Alzheimer's \& Dementia | (2019)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Low-dose ladostigil for mild cognitive impairment: A phase 2 placebo-controlled clinical trial
Schneider, Lon S, Geffen, Yona, Rabinowitz, Jonathan, **Thomas, Ronald G**, Schmidt, Reinhold, Ropele, Stefan, Weinstock, Marta, Ladostigil Study Group, & others | Neurology | (2019)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials Cognitive decline
Links: 📄 Article
Memantine and acetylcholinesterase inhibitor use in Alzheimer’s disease clinical trials: Potential for confounding by indication
Huisa, Branko N, **Thomas, Ronald G**, Jin, Shelia, Oltersdorf, Tilman, Taylor, Curtis, & Feldman, Howard H | Journal of Alzheimer's Disease | (2019)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification
Kilian, Hett, Vinh-Thong, Ta, Gwenaelle, Catheline, Tourdias, Thomas, Manjon, Jose V, Pierrick, Coupe, Weiner, Michael W, Aisen, Paul, Petersen, Ronald, Jack Jr, Clifford R, & others | Scientific Reports (Nature Publisher Group) | (2019)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
New Perspective for Non-invasive Brain Stimulation Site Selection in Mild Cognitive Impairment: Based on Meta-and Functional Connectivity Analyses
Liu, Jiao, Zhang, Binlong, Wilson, Georgia, Kong, Jian, Weiner, Michael W, Aisen, Paul, Weiner, Michael, Petersen, Ronald, Jack Jr, Clifford R, Jagust, William, & others | Frontiers in aging neuroscience | (2019)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Cognitive decline
Prediction and classification of Alzheimer’s disease based on combined features from apolipoprotein-E genotype, cerebrospinal fluid, MR, and FDG-PET imaging biomarkers
Gupta, Yubraj, Lama, Ramesh Kumar, Kwon, Goo-Rak, Weiner, Michael W, Aisen, Paul, Weiner, Michael, Petersen, Ronald, Jack Jr, Clifford R, Jagust, William, Trojanowki, John Q, & others | Frontiers in computational neuroscience | (2019)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Neuroimaging Biomarkers
Links: 📄 Article • 📋 Open Access PDF
Quantitative 18F-AV1451 brain tau PET imaging in cognitively normal older adults, mild cognitive impairment, and Alzheimer's disease patients
Zhao, Qian, Liu, Min, Ha, Lingxia, Zhou, Yun, Weiner, Michael W, Aisen, Paul, Weiner, Michael, Petersen, Ronald, Jack Jr, Clifford R, Jagust, William, & others | Frontiers in neurology | (2019)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Neuroimaging Cognitive decline
Safety and efficacy of edonerpic maleate for patients with mild to moderate Alzheimer disease: a phase 2 randomized clinical trial
Schneider, Lon S, **Thomas, Ronald G**, Hendrix, Suzanne, Rissman, Robert A, Brewer, James B, Salmon, David P, Oltersdorf, Tilman, Okuda, Tomohiro, Feldman, Howard H, & others | JAMA neurology | (2019)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
The Alzheimer Prevention Initiative Generation Program: Evaluation of CNP520 in Preclinical Alzheimer’s Disease (P4. 1-005)
Borowsky, Beth, Lopez, Cristina Lopez, Tariot, Pierre, Caputo, Angelika, Liu, Fonda, Riviere, Marie-Emmanuelle, Rouzade-Dominguez, Marie-Laure, **Thomas, Ronald**, Langbaum, Jessica, Viglietta, Vissia, & others | (2019)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Prevention trials
Links: 📄 Article
The Alzheimer's Prevention Initiative Generation Program: study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer's disease
Lopez, Cristina Lopez, Tariot, Pierre N, Caputo, Angelika, Langbaum, Jessica B, Liu, Fonda, Riviere, Marie-Emmanuelle, Langlois, Carolyn, Rouzade-Dominguez, Marie-Laure, Zalesak, Martin, Hendrix, Suzanne, & others | Alzheimer's \& Dementia: Translational Research \& Clinical Interventions | (2019)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Prevention trials
Links: 📄 Article
2018
18F-florbetapir Positron Emission Tomography--determined Cerebral beta-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery
Klinger, Rebecca Y, James, Olga G, Borges-Neto, Salvador, Bisanar, Tiffany, Li, Yi-Ju, Qi, Wenjing, Berger, Miles, Terrando, Niccolo, Newman, Mark F, Doraiswamy, P Murali, & others | Anesthesiology | (2018)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Cognitive decline
Adeno-associated viral vector (serotype 2)--nerve growth factor for patients with alzheimer disease: a randomized clinical trial
Rafii, Michael S, Tuszynski, Mark H, **Thomas, Ronald G**, Barba, David, Brewer, James B, Rissman, Robert A, Siffert, Joao, Aisen, Paul S, AAV2-NGF Study Team, & others | JAMA neurology | (2018)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
Memantine and Cholinesterase Inhibitor Use in Alzheimer Disease Trials: Potential for Confounding by Indication (P6. 178)
Huisa, Branko, **Thomas, Ronald**, Jin, Shelia, Oltersdorf, Tilman, Taylor, Curtis, & Feldman, Howard | (2018)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
P3-032: SCREENING-TO-BASELINE COGNITIVE VARIABILITY DOES NOT PREDICT RATE OF DECLINE IN A CLINICAL TRIAL OF MILD-TO-MODERATE AD
Jacobs, Diane M, **Thomas, Ronald G**, Salmon, David P, Huisa, Branko N, Feldman, Howard H, & Schneider, Lon S | Alzheimer's \& Dementia | (2018)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials Cognitive decline
P4-209: A PUBLIC RESOURCE OF BASELINE DATA FROM THE API AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE COLOMBIA TRIAL
Reiman, Eric M, Sink, Kaycee M, Hu, Nan, Guthrie, Heather, Smith, Jillian, Cho, William, Knoll, Katie L, Langbaum, Jessica B, **Thomas, Ronald G**, Toga, Arthur W, & others | Alzheimer's \& Dementia | (2018)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article • 📋 Open Access PDF
Subjective cognitive decline is associated with altered default mode network connectivity in individuals with a family history of Alzheimer’s disease
Verfaillie, Sander CJ, Binette, Alexa Pichet, Vachon-Presseau, Etienne, Tabrizi, Shirin, Savard, Melissa, Bellec, Pierre, Ossenkoppele, Rik, Scheltens, Philip, van der Flier, Wiesje M, Breitner, John CS, & others | Biological Psychiatry: Cognitive Neuroscience and Neuroimaging | (2018)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort
Tariot, Pierre N, Lopera, Francisco, Langbaum, Jessica B, **Thomas, Ronald G**, Hendrix, Suzanne, Schneider, Lon S, Rios-Romenets, Silvia, Giraldo, Margarita, Acosta, Natalia, Tobon, Carlos, & others | Alzheimer's \& Dementia: Translational Research \& Clinical Interventions | (2018)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Drug development Prevention trials
Links: 📄 Article
2017
A phase 3 trial of IV immunoglobulin for Alzheimer disease
Relkin, Norman R, **Thomas, Ronald G**, Rissman, Robert A, Brewer, James B, Rafii, Michael S, Van Dyck, Christopher H, Jack, Clifford R, Sano, Mary, Knopman, David S, Raman, Rema, & others | Neurology | (2017)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article • 📋 Open Access PDF
APOE genotype and early beta-amyloid accumulation in older adults without dementia
Lim, Yen Ying, Mormino, Elizabeth C, Alzheimer's Disease Neuroimaging Initiative, & others | Neurology | (2017)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R
Links: 📄 Article
Adding recognition discriminability index to the delayed recall is useful to predict conversion from mild cognitive impairment to Alzheimer's disease in the Alzheimer's disease neuroimaging initiative
Russo, Mar\'\i | Frontiers in aging neuroscience | (2017)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Neuroimaging Cognitive decline
Alzheimer disease brain atrophy subtypes are associated with cognition and rate of decline
Risacher, Shannon L, Anderson, Wesley H, Charil, Arnaud, Castelluccio, Peter F, Shcherbinin, Sergey, Saykin, Andrew J, Schwarz, Adam J, Alzheimer's Disease Neuroimaging Initiative, & others | Neurology | (2017)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article • 📋 Open Access PDF
Construction and analysis of weighted brain networks from sice for the study of Alzheimer's disease
Munilla, Jorge, Ortiz, Andres, Gorriz, Juan M, Ramirez, Javier, Weiner, Michael W, Aisen, Paul, Weiner, Michael, Petersen, Ronald, Jack Jr, Clifford R, Jagust, William, & others | Frontiers in neuroinformatics | (2017)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Statistical methods
Links: 📄 Article
Conversion discriminative analysis on mild cognitive impairment using multiple cortical features from MR images
Guo, Shengwen, Lai, Chunren, Wu, Congling, Cen, Guiyin, Weiner, Michael W, Aisen, Paul, Weiner, Michael, Petersen, Ronald, Jack Jr, Clifford R, Jagust, William, & others | Frontiers in aging neuroscience | (2017)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Cognitive decline Statistical methods
Links: 📄 Article
Randomized controlled trials in mild cognitive impairment: sources of variability
Petersen, Ronald C, **Thomas, Ronald G**, Aisen, Paul S, Mohs, Richard C, Carrillo, Maria C, Albert, Marilyn S, Alzheimer's Disease Neuroimaging Initiative (ADNI, & others | Neurology | (2017)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials Cognitive decline
Links: 📄 Article
Robust identification of Alzheimer’s disease subtypes based on cortical atrophy patterns
Park, Jong-Yun, Na, Han Kyu, Kim, Sungsoo, Kim, Hyunwook, Kim, Hee Jin, Seo, Sang Won, Na, Duk L, Han, Cheol E, & Seong, Joon-Kyung | Scientific reports | (2017)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
The Alzheimer's Prevention Initiative (API) Generation Program: Evaluating the Efficacy of the BACE-1 Inhibitor CNP520 in Preclinical Alzheimer's Disease
Tariot, Pierre, Lopez-Lopez, Cristina, Caputo, Angelika, **Thomas, Ronald G**, Langbaum, Jessica, Lenz, Robert, Vargas, Gabriel, Viglietta, Vissia, Reiman, Eric M, & Graf, Ana | NEUROPSYCHOPHARMACOLOGY | (2017)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Prevention trials
Links: 📄 Article
The Alzheimer’s Prevention Initiative Generation Program: evaluating CNP520 efficacy in the prevention of Alzheimer’s disease
Lopez, C Lopez, Caputo, A, Liu, F, Riviere, ME, Rouzade-Dominguez, ML, Thomas, RG, Langbaum, JB, Lenz, R, Reiman, EM, Graf, A, & others | J Prev Alzheimers Dis | (2017)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Prevention trials
Links: 📄 Article
[O5--01--02]: RATIONALE FOR SELECTION OF PRIMARY ENDPOINTS IN THE ALZHEIMER PREVENTION INITIATIVE GENERATION STUDY IN COGNITIVELY HEALTHY APOE4 HOMOZYGOTES
Caputo, Angelika, Racine, Amy, Paule, Ines, Martens, Edwin P, Tariot, Pierre, Langbaum, Jessica B, **Thomas, Ronald G**, Hendrix, Suzanne, Ryan, J Michael, Lopez-Lopez, Cristina, & others | Alzheimer's \& Dementia | (2017)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline Prevention trials
Links: 📄 Article
[P4--573]: A PHASE 2 MULTICENTER, RANDOMIZED, PLACEBO-CONTROLLED TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF EDONERPIC (T-817) IN PATIENTS WITH MILD TO MODERATE ALZHEIMER's DISEASE
Schneider, Lon S, **Thomas, Ronald G**, Hendrix, Suzanne, Brewer, James B, Rissman, Robert A, Salmon, David P, Kobayashi, Hiroshi, & Feldman, Howard H | Alzheimer's \& Dementia | (2017)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
2016
A semi-mechanism approach based on MRI and proteomics for prediction of conversion from mild cognitive impairment to Alzheimer’s disease
Liu, Haochen, Zhou, Xiaoting, Jiang, Hao, He, Hua, & Liu, Xiaoquan | Scientific reports | (2016)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Neuroimaging Cognitive decline
Links: 📄 Article • 📋 Open Access PDF
Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease
Gelmont, David, **Thomas, Ronald G**, Britt, Jonathan, Dyck-Jones, Jacqueline A, Doralt, Jennifer, Fritsch, Sandor, Brewer, James B, Rissman, Robert A, & Aisen, Paul | Alzheimer's \& Dementia: Translational Research \& Clinical Interventions | (2016)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits
Deming, Yuetiva, Xia, Jian, Cai, Yefei, Lord, Jenny, Del-Aguila, Jorge L, Fernandez, Maria Victoria, Carrell, David, Black, Kathleen, Budde, John, Ma, ShengMei, & others | Scientific Reports | (2016)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Biomarkers
Links: 📄 Article
Longitudinal decline in mild-to-moderate Alzheimer's disease: analyses of placebo data from clinical trials
**Thomas, Ronald G**, Albert, Marilyn, Petersen, Ronald C, & Aisen, Paul S | Alzheimer's \& Dementia | (2016)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Longitudinal studies
Links: 📄 Article
The Alzheimer's Prevention Initiative Generation Study: A Preclinical Trial in APOE4 Homozygotes
Tariot, Pierre, Langbaum, Jessica, Schneider, Lon, **Thomas, Ronald G**, Graf, Ana, Lopez-Lopez, Cristina, Caputo, Angelika, Lenz, Robert, Vargas, Gabriel, & Reiman, Eric M | NEUROPSYCHOPHARMACOLOGY | (2016)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Prevention trials
Links: 📄 Article
2015
A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
Turner, R Scott, **Thomas, Ronald G**, Craft, Suzanne, Van Dyck, Christopher H, Mintzer, Jacobo, Reynolds, Brigid A, Brewer, James B, Rissman, Robert A, Raman, Rema, Aisen, Paul S, & others | Neurology | (2015)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
Large-scale genomics unveil polygenic architecture of human cortical surface area
Chen, Chi-Hua, Peng, Qian, Schork, Andrew J, Lo, Min-Tzu, Fan, Chun-Chieh, Wang, Yunpeng, Desikan, Rahul S, Bettella, Francesco, Hagler, Donald J, Westlye, Lars T, & others | Nature communications | (2015)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials
Donohue, Michael C, Moghadam, Setareh H, Roe, Allyson D, Sun, Chung-Kai, Edland, Steven D, **Thomas, Ronald G**, Petersen, Ronald C, Sano, Mary, Galasko, Douglas, Aisen, Paul S, & others | Alzheimer's \& Dementia | (2015)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Longitudinal studies
Peripheral and central effects of $\\gamma$-secretase inhibition by semagacestat in Alzheimer’s disease
Doody, Rachelle S, Raman, Rema, Sperling, Reisa A, Seimers, Eric, Sethuraman, Gopalan, Mohs, Richard, Farlow, Martin, Iwatsubo, Takeshi, Vellas, Bruno, Sun, Xiaoying, & others | Alzheimer's research \& therapy | (2015)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Resveratrol is safe and well-tolerated in individuals with mild-moderate dementia due to Alzheimer’s disease.(S33. 009)
Turner, R, **Thomas, Ronald**, Craft, Suzanne, van Dyck, Christopher, Mintzer, Jacobo, Reynolds, Brigid, Brewer, James, Rissman, Robert, Raman, Rema, & Aisen, Paul | (2015)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Safety of Intravenous Immunoglobulin Therapy in Patients with Probable Alzheimer's Disease: A Randomized, Placebo-Controlled Clinical Study
Gelmont, D, Thomas, RG, Dyck-Jones, JA, Fritsch, S, Aisen, P, & Relkin, N | ANNALS OF ALLERGY ASTHMA \& IMMUNOLOGY | (2015)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Drug development
Links: 📄 Article
Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer’s disease
Orban, Pierre & Madjar, C\'e | Scientific data | (2015)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Neuroimaging
Links: 📄 Article • 📋 Open Access PDF
Using novel methodologies to examine the impact of artificial light at night on the cortisol stress response in dispersing Atlantic salmon (Salmo salar L.) fry
Newman, Rhian C, Ellis, Tim, Davison, Phil I, Ives, Mark J, Thomas, Rob J, Griffiths, Sian W, & Riley, William D | Conservation physiology | (2015)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Statistical methods
Links: 📄 Article • 📋 Open Access PDF
2014
Alzheimer’s Disease Cooperative Study Steering Committee; Solanezumab study group. Phase 3 trials of solanezumab for mild-to-moderate Alzheimer’s disease
Doody, RS, Thomas, RG, Farlow, M, Iwatsubo, T, Vellas, B, Joffe, S, Kieburtz, K, Raman, R, Sun, X, Aisen, PS, & others | N Engl J Med | (2014)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Australian imaging, biomarkers, and lifestyle flagship study of ageing; Alzheimer’s disease neuroimaging initiative; Alzheimer’s disease cooperative study. The preclinical Alzheimer cognitive composite: measuring amyloid-related decline
Donohue, MC, Sperling, RA, Salmon, DP, Rentz, DM, Raman, R, Thomas, RG, Weiner, M, & Aisen, PS | JAMA Neurol | (2014)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Neuroimaging Biomarkers Cognitive decline
Bayesian Longitudinal Modeling on Placebo Data from Alzheimer’s Disease Clinical Studies (P1. 010)
Chen, Yun-Fei, Mohs, Richard, Ding, Ying, Aisen, Paul, & **Thomas, Ronald** | (2014)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Longitudinal studies
Links: 📄 Article • 📋 Open Access PDF
Clinical trial of an inhibitor of RAGE-A beta interactions in Alzheimer disease
Galasko, Douglas, Bell, Joanne, Mancuso, Jessica Y, Kupiec, James W, Sabbagh, Marwan N, van Dyck, Christopher, **Thomas, Ronald G**, Aisen, Paul S, & others | Neurology | (2014)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
Estimating long-term multivariate progression from short-term data
Donohue, Michael C, Jacqmin-Gadda, Hene, Le Goff, Melanie, **Thomas, Ronald G**, Raman, Rema, Gamst, Anthony C, Beckett, Laurel A, Jack Jr, Clifford R, Weiner, Michael W, Dartigues, Jean-Francois, & others | Alzheimer's \& Dementia | (2014)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
F3-02-02: MODELING LONG-TERM DISEASE PROGRESSION WITH COVARIATES
Donohue, Michael C, Gamst, Anthony, Jack, Clifford, Beckett, Laurel, Weiner, Michael, Aisen, Paul, Raman, Rema, & **Thomas, Ronald** | Alzheimer's \& Dementia | (2014)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
P1-357: ADCS EDC: INVESTIGATIONAL PRODUCT MANAGEMENT SYSTEM
Jimenez-Maggiora, Gustavo Adolfo, **Thomas, Ronald G**, Qiu, Hongmei, Hong, Phuoc, & Aisen, Paul S | Alzheimer's \& Dementia | (2014)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Phase 3 trials of solanezumab and bapineuzumab for Alzheimer’s disease
Laske, Christoph | N Engl J Med | (2014)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease
Doody, Rachelle S, **Thomas, Ronald G**, Farlow, Martin, Iwatsubo, Takeshi, Vellas, Bruno, Joffe, Steven, Kieburtz, Karl, Raman, Rema, Sun, Xiaoying, Aisen, Paul S, & others | New England Journal of Medicine | (2014)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
The preclinical Alzheimer cognitive composite: measuring amyloid-related decline
Donohue, Michael C, Sperling, Reisa A, Salmon, David P, Rentz, Dorene M, Raman, Rema, **Thomas, Ronald G**, Weiner, Michael, & Aisen, Paul S | JAMA neurology | (2014)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article
2013
A phase 3 trial of semagacestat for treatment of Alzheimer's disease
Doody, Rachelle S, Raman, Rema, Farlow, Martin, Iwatsubo, Takeshi, Vellas, Bruno, Joffe, Steven, Kieburtz, Karl, He, Feng, Sun, Xiaoying, **Thomas, Ronald G**, & others | New England Journal of Medicine | (2013)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Drug development
Links: 📄 Article
Age and apolipoprotein E genotype influence rate of cognitive decline in nondemented elderly.
Salmon, David P, Ferris, Steven H, **Thomas, Ronald G**, Sano, Mary, Cummings, Jeffery L, Sperling, Reisa A, Petersen, Ronald C, & Aisen, Paul S | Neuropsychology | (2013)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Cognitive decline
Alzheimer’s Disease Cooperative Study Steering Committee, Siemers E, Sethuraman G, Mohs R, Semagacestat Study Group. A phase 3 trial of semagacestat for treatment of Alzheimer’s disease
Doody, RS, Raman, R, Farlow, M, Iwatsubo, T, Vellas, B, Joffe, S, Kieburtz, K, He, F, Sun, X, Thomas, RG, & others | N Engl J Med | (2013)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Drug development
Links: 📄 Article • 📋 Open Access PDF
Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: a new approach
Posner, Holly B, Cano, Stefan, Carrillo, Maria C, Selnes, Ola, Stern, Yaakov, **Thomas, Ronald G**, Zajicek, John, Hobart, Jeremy, Alzheimer's Disease Neuroimaging Initiative, & others | Alzheimer's \& Dementia | (2013)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
P1--332: Evaluation of the relationship between TTP488 plasma concentrations and changes in ADAS-cog relative to placebo
Burstein, Aaron, Galasko, Douglas, Aisen, Paul, **Thomas, Ronald**, Grimes, Imogene, Clark, David J, Mjalli, Adnan, & Orlande, Cesare | Alzheimer's \& Dementia | (2013)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
P3--295: The Placebo Data Analysis in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) Clinical Trials Project: Overview of progress in trial data collection, and key findings from the pooled Alzheimer's disease trial datasets
**Thomas, Ronald**, Petersen, Ronald, Siuciak, Judith, Carrillo, Maria, Albert, Marilyn, Aisen, Paul, Alzheimer's Disease Neuroimaging Initiative, & Foundation for NIH Biomarkers Consortium AD MCI Placebo Data Project Team | Alzheimer's \& Dementia | (2013)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Cognitive decline Statistical methods
Links: 📄 Article
P4--157: Adcs electronic data capture: Collaborative development and management of clinical trial databases
Jimenez-Maggiora, Gustavo, **Thomas, Ronald**, Bruschi, Stefania, Qiu, Hongmei, Hong, Phuoc, & Aisen, Paul | Alzheimer's \& Dementia | (2013)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials
Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial
Mills, Sarah M, Mallmann, J, Santacruz, Anna M, Fuqua, A, Carril, M, Aisen, Paul S, Althage, MC, Belyew, S, Benzinger, Tammie L, Brooks, William S, & others | Revue neurologique | (2013)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials
Links: 📄 Article
Putting the Alzheimer's cognitive test to the test II: Rasch Measurement Theory
Hobart, Jeremy, Cano, Stefan, Posner, Holly, Selnes, Ola, Stern, Yaakov, **Thomas, Ronald**, Zajicek, John, & Alzheimer's Disease Neuroimaging Initiative | Alzheimer's \& dementia | (2013)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article
2012
A Garden before the Garden: Landscape, History and the National Botanic Garden of Wales
Austin, David & Thomas, Rob | Landscapes | (2012)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Alzheimer’s Disease Cooperative Study. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures
Galasko, DR, Peskind, E, Clark, CM, Quinn, JF, Ringman, JM, Jicha, GA, Cotman, C, Cottrell, B, Montine, TJ, Thomas, RG, & others | Arch Neurol | (2012)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Biomarkers
Alzheimer’s disease therapeutic trials: EU/US Task Force report on recruitment, retention, and methodology
Vellas, B, Hampel, H, & Roug\'e | The journal of nutrition, health \& aging | (2012)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Statistical methods
Links: 📄 Article
Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures
Galasko, Douglas R, Peskind, Elaine, Clark, Christopher M, Quinn, Joseph F, Ringman, John M, Jicha, Gregory A, Cotman, Carl, Cottrell, Barbara, Montine, Thomas J, **Thomas, Ronald G**, & others | Archives of neurology | (2012)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Biomarkers
Links: 📄 Article
Incidence of new-onset seizures in mild to moderate Alzheimer disease
Irizarry, Michael C, Jin, Shelia, He, Feng, Emond, Jennifer A, Raman, Rema, **Thomas, Ronald G**, Sano, Mary, Quinn, Joseph F, Tariot, Pierre N, Galasko, Douglas R, & others | Archives of neurology | (2012)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
O3-13-05: The Gammaglobulin Alzheimer Partnership Study (GAP): Design, screening, enrollment and futility analysis results
Relkin, Norman, Gessert, Devon, Stokes, Karen, Adamiak, Basia, Ngo, Leock Y, **Thomas, Ronald**, Gelmont, David, & Aisen, Paul | Alzheimer's \& Dementia | (2012)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Statistical methods
Links: 📄 Article • 📋 Open Access PDF
P3-364: ADCS EDC
Jimenez-Maggiora, Gustavo, **Thomas, Ronald**, Hong, Phuoc, & Aisen, Paul | Alzheimer's \& Dementia | (2012)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
P3-383: ADCS data sharing
**Thomas, Ronald**, Jimenez, Gustavo, Brewer, James, Rissman, Robert A, & Aisen, Paul | Alzheimer's \& Dementia | (2012)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
P3-384: The placebo data analysis in Alzheimer's disease and mild cognitive impairment (MCI) clinical trials project: Overview of progress in trial data collection, and key findings from the pooled MCI trial datasets
Aisen, Paul, **Thomas, Ronald**, Carrillo, Maria, Mohs, Richard, Petersen, Ronald, Siuciak, Judith, Albert, Marilyn, Alzheimer's Disease Neuroimaging Initiative, & Foundation for NIH Biomarkers Consortium CSF Proteomics Project Team | Alzheimer's \& Dementia | (2012)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Cognitive decline Statistical methods
2011
A phase II trial of huperzine A in mild to moderate Alzheimer disease
Rafii, MS, Walsh, S, Little, JT, Behan, K, Reynolds, B, Ward, C, Jin, S, Thomas, R, Aisen, PS, & others | Neurology | (2011)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease
Sano, M, Bell, KL, Galasko, D, Galvin, JE, Thomas, RG, Van Dyck, CH, & Aisen, PS | Neurology | (2011)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article • 📋 Open Access PDF
Adding delayed recall to the Alzheimer Disease Assessment Scale is useful in studies of mild cognitive impairment but not Alzheimer disease
Sano, Mary, Raman, Rema, Emond, Jennifer, **Thomas, Ronald G**, Petersen, Ronald, Schneider, Lon S, & Aisen, Paul S | Alzheimer disease and associated disorders | (2011)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article
Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease
Tariot, Pierre N, Schneider, Lon S, Cummings, Jeffrey, **Thomas, Ronald G**, Raman, Rema, Jakimovich, Laura J, Loy, Rebekah, Bartocci, Barbara, Fleisher, Adam, Ismail, M Saleem, & others | Archives of General Psychiatry | (2011)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Chronic divalproex sodium use and brain atrophy in Alzheimer disease
Fleisher, AS, Truran, D, Mai, JT, Langbaum, JBS, Aisen, PS, Cummings, JL, Jack, CR, Weiner, MW, Thomas, RG, Schneider, LS, & others | Neurology | (2011)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Dietary self-monitoring and its impact on weight loss in overweight children
Mockus, Danyte S, Macera, Caroline A, Wingard, Deborah L, Peddecord, Michael, **Thomas, Ronald G**, & Wilfley, Denise E | International Journal of Pediatric Obesity | (2011)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Omega-3 Fatty Acids for Alzheimer's Disease. What a Pill Can Tell Us about Eating Fish
Quinn, JF, Raman, R, Thomas, RG, Yurko-Mauro, K, Nelson, EB, Van Dyck, C, Galvin, JE, Emond, J, Jack Jr, CR, Weiner, M, & others | (2011)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
P3-406: Role of caregiver in subject's compliance with treatment
Messick, Viviana, Donohue, Michael, Raman, Rema, Sano, Mary, Quinn, Joseph, Thomas, Ron, Emond, Jennifer, & Aisen, Paul | Alzheimer's \& Dementia | (2011)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Drug development
Links: 📄 Article
Radiological follow up of perineal repair with cross-linked acellular porcine dermal collagen following extralevator abdominoperineal excision for low rectal cancer: P115
Smart, N, George, A, Khan, D, Thomas, R, & Daniels, I | Colorectal Disease | (2011)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Longitudinal studies
Links: 📄 Article
Report of the task force on designing clinical trials in early (predementia) AD
Aisen, PS, Andrieu, S, Sampaio, C, Carrillo, M, Khachaturian, ZS, Dubois, Bruno, Feldman, HH, Petersen, RC, Siemers, E, Doody, RS, & others | Neurology | (2011)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Clinical trials
Links: 📄 Article
The relative efficiency of time-to-threshold and rate of change in longitudinal data
Donohue, Michael C, Gamst, AC, Thomas, RG, Xu, R, Beckett, L, Petersen, Ronald Carl, Weiner, MW, Aisen, P, Alzheimer's Disease Neuroimaging Initiative, & others | Contemporary clinical trials | (2011)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Longitudinal studies
Links: 📄 Article • 📋 Open Access PDF
2010
Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans
Aisen, Paul S, Petersen, Ronald C, Donohue, Michael C, Gamst, Anthony, Raman, Rema, **Thomas, Ronald G**, Walter, Sarah, Trojanowski, John Q, Shaw, Leslie M, Beckett, Laurel A, & others | Alzheimer's \& Dementia | (2010)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Neuroimaging
Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial
Quinn, Joseph F, Raman, Rema, **Thomas, Ronald G**, Yurko-Mauro, Karin, Nelson, Edward B, Van Dyck, Christopher, Galvin, James E, Emond, Jennifer, Jack, Clifford R, Weiner, Michael, & others | Jama | (2010)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Cognitive decline
Links: 📄 Article
O3-01-07: Rate of decline in ADNI normal controls with evidence of amyloid burden
Donohue, Michael, Gamst, Anthony, Thomas, Ron, Brewer, Jim, Weiner, Michael, & Aisen, Paul | Alzheimer's \& Dementia | (2010)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
P1-433: Brain volume changes with divalproex sodium in Alzheimer's disease
Fleisher, Adam S, Jack Jr, Clifford R, Weiner, Michael W, Truran, Diana, Mai, Jacqueline, Aisen, Paul S, Cummings, Jeffrey L, **Thomas, Ronald G**, Schneider, Lon S, & Tariot, Pierre N | Alzheimer's \& Dementia | (2010)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
P1-447: Cerebrospinal fluid biomarker outcomes in a trial of docosahexaenoic acid (DHA) for Alzheimer's disease
Quinn, Joseph F, **Thomas, Ronald**, Raman, Rema, Yurko-Mauro, Karin, Bailey-Hall, Eileen, Nelson, Edward, Shaw, Les, & Aisen, Paul | Alzheimer's \& Dementia | (2010)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Biomarkers
2009
MRI substudy participation in Alzheimer disease (AD) clinical trials: baseline comparability of a substudy sample to entire study population
Raman, Rema, **Thomas, Ronald G**, Weiner, Michael W, Jack, Clifford R, Ernstrom, Karin, Aisen, Paul S, Tariot, Pierre N, & Quinn, Joseph F | Alzheimer disease and associated disorders | (2009)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Neuroimaging Epidemiology
Links: 📄 Article
O1-04-02: A clinical trial of docosahexanoic acid (DHA) for the treatment of Alzheimer's disease
Quinn, Joseph F, Raman, Rema, **Thomas, Ronald G**, Ernstrom, Karin, Yurko-Mauro, Karin, Nelson, Edward B, Shinto, Lynne, Nair, Anil K, & Aisen, Paul | Alzheimer's \& Dementia | (2009)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Drug development
Links: 📄 Article
O1-04-03: The ADCS valproate neuroprotection trial: Primary efficacy and safety results
Tariot, Pierre N, Aisen, Paul, Cummings, Jeffrey, Jakimovich, Laura, Schneider, Lon, **Thomas, Ronald**, Becerra, Lida, & Loy, Rebekah | Alzheimer's \& Dementia | (2009)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R
Links: 📄 Article
O4-04-07: The ADAS-cog's performance as a measure—lessons from the ADNI study: Part 2-evaluation using modern psychometric methods
Cano, Stefan, Posner, Holly, Aisen, Paul, Selnes, Ola, Stern, Yaakov, **Thomas, Ronald**, Weiner, Michael, Zajicek, John, Zeger, Scott, & Hobart, Jeremy | Alzheimer's \& Dementia | (2009)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Statistical methods
P1-269: The ADAS-cog's performance as a measure-lessons from the ADNI study: Part 1-evaluation using traditional psychometric methods
Posner, Holly, Cano, Stefan, Aisen, Paul, Selnes, Ola, Stern, Yaakov, **Thomas, Ronald**, Weiner, Michael, Zajicek, John, Zeger, Scott, & Hobart, Jeremy | Alzheimer's \& Dementia | (2009)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Statistical methods
Links: 📄 Article
P1-270: The ADAS-cog's performance as a measure-lessons from the ADNI study: Part 3-do the scale modifications add value?
Hobart, Jeremy, Posner, Holly, Aisen, Paul, Selnes, Ola, Stern, Yaakov, **Thomas, Ronald**, Weiner, Michael, Zajicek, John, Zeger, Scott, & Cano, Stefan | Alzheimer's \& Dementia | (2009)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Plasma urate and progression of mild cognitive impairment
Irizarry, Michael C, Raman, Rema, Schwarzschild, Michael A, Becerra, Lida M, **Thomas, Ronald G**, Peterson, Ronald C, Ascherio, Alberto, & Aisen, Paul S | Neurodegenerative Diseases | (2009)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Cognitive decline
Links: 📄 Article
REVIEWS IN THE NEUROSCIENCES
Machado, C, Leisman, G, Koch, P, Rodriguez, R, Caiballo, M, Korein, J, Sanchez-Catasus, C, Perez, J, Djuric, S, Djuric, V, & others | NEUROSCIENCES | (2009)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
The ADAS-cog's Performance as a Measure Lessons from the ADNI Study: Part 1-Evaluation Using Traditional Psychometric Methods
Pasner, Holly, Cano, Stefan J, Aisen, Paul, Selnes, Ola, Stern, Yaakov, **Thomas, Ronald**, Weiner, Michael, Zajicek, John, Zeger, Scott, & Hobart, Jeremy | Neurology | (2009)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Statistical methods
Links: 📄 Article
2008
A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium
Khachaturian, Zaven S, Petersen, Ronald C, Gauthier, Serge, Buckholtz, Neil, Corey-Bloom, Jodey P, Evans, Bill, Fillit, Howard, Foster, Norman, Greenberg, Barry, Grundman, Michael, & others | Alzheimer's \& dementia: the journal of the Alzheimer's Association | (2008)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Prevention trials
Links: 📄 Article • 📋 Open Access PDF
Alzheimer Disease Cooperative Study. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
Aisen, PS, Schneider, LS, Sano, M, Diaz-Arrastia, R, Van Dyck, CH, Weiner, MF, Bottiglieri, T, Jin, S, Stokes, KT, Thomas, RG, & others | Jama | (2008)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Cognitive decline
Ametropia, preschoolers' cognitive abilities, and effects of spectacle correction
Roch-Levecq, Anne-Catherine, Brody, Barbara L, **Thomas, Ronald G**, & Brown, Stuart I | Archives of ophthalmology | (2008)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Cognitive decline
Links: 📄 Article
Dimebon investigators: Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study
Doody, RS, Gavrilova, SI, Sano, M, Thomas, RG, Aisen, PS, Bachurin, SO, Seely, L, & Hung, D | Lancet | (2008)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Dual Task Test Could Help Diagnose Dementia
Aisen, Paul S, Schneider, Lon S, Sano, Mary, Diaz-Arrastia, Ramon, van Dyck, Christopher H, Weiner, Myron F, Bottiglieri, Teodoro, Jin, Shelia, Stokes, Karen T, **Thomas, Ronald G**, & others | JAMA | (2008)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R
Links: 📄 Article
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study
Doody, Rachelle S, Gavrilova, Svetlana I, Sano, Mary, **Thomas, Ronald G**, Aisen, Paul S, Bachurin, Sergey O, Seely, Lynn, Hung, David, & others | The Lancet | (2008)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Efficacy of site-independent telemedicine in the STRokE DOC trial: a randomised, blinded, prospective study
Meyer, Brett C, Raman, Rema, Hemmen, Thomas, Obler, Richard, Zivin, Justin A, Rao, Ramesh, **Thomas, Ronald G**, & Lyden, Patrick D | The Lancet Neurology | (2008)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R
Links: 📄 Article
High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
Aisen, Paul S, Schneider, Lon S, Sano, Mary, Diaz-Arrastia, Ramon, Van Dyck, Christopher H, Weiner, Myron F, Bottiglieri, Teodoro, Jin, Shelia, Stokes, Karen T, **Thomas, Ronald G**, & others | Jama | (2008)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Cognitive decline
O2-04--06: Randomized clinical trial of antioxidant treatment in Alzheimer's disease with CSF biomarker measures
Galasko, Douglas, Peskind, Elaine, Clark, Christopher M, Quinn, Joseph, Ringman, John, Jicha, Gregory A, Cottrell, Barbara, & **Thomas, Ronald G** | Alzheimer's \& Dementia | (2008)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Biomarkers Drug development
Links: 📄 Article
P4-337: Dimebon improves cognition, function, and behavior in mild and moderate Alzheimer's disease: Results by severity of a one-year, double-blind, placebo-controlled study
Doody, Rachelle S, Gavrilova, Svetlana, **Thomas, Ronald**, Aisen, Paul, Bachurin, Sergey, Seely, Lynn, & Hung, David | Alzheimer''s and Dementia | (2008)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
P4-343: Omega 3 fatty acids and Alzheimer's disease: Trial design and baseline study population characteristics in a clinical trial of docosahexanoic acid for Alzheimer's disease
Quinn, Joseph F, Raman, Rema, **Thomas, Ronald**, Ernstrom, Karin, Yurko-Mauro, Karin, Nelson, Edward, & Aisen, Paul S | Alzheimer's \& Dementia | (2008)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Epidemiology
P4-387: Adding delayed recall to the Alzheimer's disease assessment scale-cognitive subscale (ADAS-cog): Sensitivity in a clinical trial for Alzheimer's disease and mild cognitive impairment
Raman, Rema, Emond, Jennifer, **Thomas, Ronald G**, Petersen, Ronald C, Schneider, Lon S, Aisen, Paul S, & Sano, Mary | Alzheimer's \& Dementia | (2008)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Cognitive decline
Links: 📄 Article
Statistical treatment of withdrawal in trials of anti-dementia drugs--Authors' reply
Doody, Rachelle, Seely, Lynn, **Thomas, Ronald**, Sano, Mary, & Aisen, Paul | The Lancet | (2008)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Drug development Statistical methods
Links: 📄 Article
2007
Dimebon improves cognition, function, and behavior in patients with mild-moderate Alzheimer's disease: Results of a randomized, double-blind, placebo-controlled study
Doody, Rochelle, Gavrilova, Svetlana, Sano, Mary, **Thomas, Ronald**, Aisen, Paul, Seely, Lynn, & Hung, David | Neurology | (2007)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
P-081: The ACDS home assessment instrument: A pilot study
Sano, Mary, Kaye, Jeffrey, Ferris, Steven, Hayes, Tamara, Egelko, Susan, Mundt, James, Li, Yan, Walter, Sarah, **Thomas, Ronald**, Edland, Steven, & others | Alzheimer's \& Dementia | (2007)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Population Dynamics of Meloidogyne incognita and RotylenchulusTenchulus reniformis Alone and in Combination, and Their Effects on Sweet Potato1
THOMAS, RONALD J & CLARK, CHRISTOPHER A | (2007)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Epidemiology
Potential outcome measures and trial design issues for multiple system atrophy
May, Susanne, Gilman, Sid, Sowell, B Brooke, **Thomas, Ronald G**, Stern, Matthew B, Colcher, Amy, Tanner, Caroline M, Huang, Neng, Novak, Peter, Reich, Stephen G, & others | Movement disorders | (2007)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R
Links: 📄 Article
S3--02--01: ADCS homocysteine trial
Aisen, Paul S, Jin, Shelia, **Thomas, Ronald G**, Sano, Mary, Diaz-Arrastia, Ramon, Thal, Leon, & Alzheimer's Disease Cooperative Study NIA | Alzheimer's \& Dementia | (2007)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R
Links: 📄 Article
S3--02--03: Results of a one-year randomized, placebo-controlled trial of dimebon for the treatment of mild to moderate Alzheimer's disease
Doody, Rachelle S, Gavrilova, Svetlana, Sano, Mary, **Thomas, Ronald**, Aisen, Paul, Bachurin, Sergey, Seely, Lynn, & Hung, David | Alzheimer's \& Dementia | (2007)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Drug development
2006
ADCS Prevention Instrument Project: pharmacoeconomics: assessing health-related resource use among healthy elderly
Sano, Mary, Zhu, Carolyn W, Whitehouse, Peter J, Edland, Steven, Jin, Shelia, Ernstrom, Karin, **Thomas, Ronald G**, Thal, Leon J, & Ferris, Steven H | Alzheimer disease and associated disorders | (2006)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Prevention trials
Links: 📄 Article
Cognitive Changes in the Treatment of Mild Cognitive Impairment with Donepezil and Vitamin E: P02. 187
Petersen, Ronald, **Thomas, Ronald**, Grundman, Michael, & Thai, Leon | Neurology | (2006)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Cognitive decline Drug development
2005
Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers
Krajewska, Maryla, Kim, Hoguen, Kim, Chul, Kang, Haeyoun, Welsh, Kate, Matsuzawa, Shu-ichi, Tsukamoto, Michelle, **Thomas, Ronald G**, Assa-Munt, Nuria, Piao, Zhe, & others | Clinical Cancer Research | (2005)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Biomarkers Statistical methods
Links: 📄 Article
Cognition in the treatment of mild cognitive impairment with donepezil and vitamin E
Pfeiffer, E, Petersen, RC, Thomas, RG, & Thal, LJ | INTERNATIONAL PSYCHOGERIATRICS | (2005)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Cognitive decline Drug development
Links: 📄 Article
Cognitive Outcomes of Corrective Lenses on Low Income Preschoolers With Hyperopia/Astimgatism: A Longitudinal Pilot Study
Roch--Levecq, A--C, Brody, B, Thomas, RG, & Brown, SI | Investigative Ophthalmology \& Visual Science | (2005)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Cognitive decline Longitudinal studies
Links: 📄 Article
Detailed assessment of activities of daily living in moderate to severe Alzheimer's disease
Galasko, D, Schmitt, F, Thomas, R, Jin, S, Bennett, D, & Ferris, S | Journal of the International Neuropsychological Society: JINS | (2005)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Divalproex sodium in nursing home residents with possible or probable Alzheimer disease complicated by agitation: a randomized, controlled trial
Tariot, Pierre N, Raman, Rema, Jakimovich, Laura, Schneider, Lon, Porsteinsson, Anton, **Thomas, Ronald**, Mintzer, Jacobo, Brenner, Ronald, Schafer, Kim, & Thal, Leon | The American journal of geriatric psychiatry | (2005)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study
Peskind, Elaine R, Tsuang, Debby W, Bonner, Lauren T, Pascualy, Marcella, Riekse, Robert G, Snowden, Mark B, **Thomas, Ronald**, & Raskind, Murray A | Alzheimer Disease \& Associated Disorders | (2005)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Sample size considerations in dementia prevention trials: Data from the Alzheimer's disease Cooperative Study MCI Trial
Edland, SD, May, S, Emond, JA, Wolfson, T, Thal, L, Petersen, RC, & Thomas, RG | NEUROLOGY | (2005)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Prevention trials
Links: 📄 Article
Self-management of age-related macular degeneration at the 6-month follow-up: a randomized controlled trial
Brody, Barbara L, Roch-Levecq, Anne-Catherine, **Thomas, Ronald G**, Kaplan, Robert M, & Brown, Stuart I | Archives of Ophthalmology | (2005)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials Longitudinal studies
Links: 📄 Article
Treatment of MCI with cholinesterase inhibitors: current data
Petersen, RC, Thomas, R, Grundman, M, & Thal, L | INTERNATIONAL PSYCHOGERIATRICS | (2005)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Drug development
Links: 📄 Article
Vitamin E and donepezil for the treatment of mild cognitive impairment
Petersen, Ronald C, **Thomas, Ronald G**, Grundman, Michael, Bennett, David, Doody, Rachelle, Ferris, Steven, Galasko, Douglas, Jin, Shelia, Kaye, Jeffrey, Levey, Allan, & others | New England Journal of Medicine | (2005)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Cognitive decline Drug development
Links: 📄 Article
[O1-04-04]: Operational criteria for patient recruitment in trials of mild cognitive impairment
Petersen, Ronald C, **Thomas, Ronald G**, Grundman, Michael, Bennett, David A, Kaye, Jeffrey, Levey, Allan I, Pfeiffer, Eric, Sano, Mary, van Dyck, Christopher H, & Thal, Leon J | Alzheimer's \& Dementia | (2005)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Cognitive decline
Links: 📄 Article
[O2-01-01]: Donepezil and vitamin E in the progression of mild cognitive impairment to Alzheimer's disease: A hazard-ratio analysis
Thal, Leon J, **Thomas, Ronald G**, Grundman, Michael, Bennett, David A, Doody, Rachelle S, Ferris, Steven H, Galasko, Douglas R, Jin, Shelia, Levey, Allan I, & Petersen, Ronald C | Alzheimer's \& Dementia | (2005)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline Statistical methods
Links: 📄 Article • 📋 Open Access PDF
2004
A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease
Hamilton, Joanne M, Salmon, David P, Galasko, Douglas, Delis, Dean C, Hansen, Lawrence A, Masliah, Eliezer, **Thomas, Ronald G**, & Thal, Leon J | Journal of the International Neuropsychological Society: JINS | (2004)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article
Distinguished From Alzheimer Disease and Normal Aging for Clinical Trials Michael Grundman, MD, MPH; Ronald C. Petersen, PhD, MD; Steven H. Ferris, PhD
**Thomas, Ronald G**, Aisen, Paul S, Shoulson, Ira, Rosenberg, Roger N, Gwinn-Hardy, Katrina, Mathews, Katherine D, Moore, Steven A, Darnell, Robert B, Lu, Chin-Song, Chou, Yah-Huei Wu, & others | (2004)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Neuroimaging
Links: 📄 Article
Donepezil and vitamin E for mild cognitive impairment
Petersen, RC, Thomas, R, & Thal, L | 9th International Congress on Alzheimer’s Disease. Philadelphia | (2004)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Cognitive decline
Links: 📄 Article • 📋 Open Access PDF
MAP kinase inhibitors reduce Helicobacter pylori-induced interleukin-8 secretion and the phosphorylation of I$\\kappa$B$\\\\alpha$
Argent, R, Thomas, R, Boughan, P, Kidd, M, Smith, J, James, M, Bajaj-Elliott, M, & Atherton, J | Helicobacter | (2004)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials
Grundman, Michael, Petersen, Ronald C, Ferris, Steven H, **Thomas, Ronald G**, Aisen, Paul S, Bennett, David A, Foster, Norman L, Jack Jr, Clifford R, Galasko, Douglas R, Doody, Rachelle, & others | Archives of neurology | (2004)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Cognitive decline
P1-003 ADCS Prevention instrument project: assessment of activities of daily living (ADL)
Galasko, Douglas, Bennett, David, Sano, Mary, Marson, Daniel, Jin, Shelia, & **Thomas, Ronald** | Neurobiology of Aging | (2004)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Prevention trials
Links: 📄 Article
P1-322 A multicenter, randomized, double-blind, placebo-controlled trial of valproate for agitation associated with dementia
Tariot, Pierre N, Thal, Leon, Jakimovich, Laura, **Thomas, Ronald**, & Raman, Rema | Neurobiology of Aging | (2004)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Clinical trials
Links: 📄 Article
Reliability of monitoring the clinical dementia rating in multicenter clinical trials
Schafer, Kimberly A, Tractenberg, Rochelle E, Sano, Mary, Mackell, Joan A, **Thomas, Ronald G**, Gamst, Anthony, Thal, Leon J, Morris, John C, & others | Alzheimer disease and associated disorders | (2004)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Clinical trials
2003
A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease
Singer, Clifford, Tractenberg, Rochelle E, Kaye, Jeffrey, Schafer, Kim, Gamst, Anthony, Grundman, Michael, **Thomas, Ronald**, & Thal, Leon J | Sleep | (2003)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Sleep disorders
A multicenter, randomized, placebo controlled, multiple-dose, safety and pharmacokinetic study of AIT-082 (Neotrofin™) in mild Alzheimer's disease patients
Grundman, M, Capparelli, E, Kim, HT, Morris, JC, Farlow, M, Rubin, EH, Heidebrink, J, Hake, A, Ho, G, Schultz, AN, & others | Life sciences | (2003)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
Alzheimer's Disease Cooperative Study. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial
Aisen, PS, Schafer, KA, Grundman, M, Pfeiffer, E, Sano, M, Davis, KL, Farlow, MR, Jin, S, Thomas, RG, & Thal, LJ | Jama | (2003)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial
Aisen, Paul S, Schafer, Kimberly A, Grundman, Michael, Pfeiffer, Eric, Sano, Mary, Davis, Kenneth L, Farlow, Martin R, Jin, Shelia, **Thomas, Ronald G**, Thal, Leon J, & others | Jama | (2003)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Estrogen levels do not correlate with improvement in cognition
Thal, Leon J, **Thomas, Ronald G**, Mulnard, Ruth, Sano, Mary, Grundman, Michael, & Schneider, Lon | Archives of Neurology | (2003)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
Fission fragment angular distributions: A probe to study heavy-ion fusion dynamics
Thomas, RG, Choudhury, RK, Mohanty, AK, Saxena, A, & Kapoor, SS | Physical Review C | (2003)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
Hippocampal volume is associated with memory but not nonmemory cognitive performance in patients with mild cognitive impairment
Grundman, Michael, Jack, Clifford R, Petersen, Ronald C, Kim, Hyun T, Taylor, Curtis, Datvian, Marina, Weiner, Myron F, DeCarli, Charles, DeKosky, Steven T, Van Dyck, Christopher, & others | Journal of Molecular Neuroscience | (2003)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Cognitive decline
Links: 📄 Article • 📋 Open Access PDF
Idebenone treatment fails to slow cognitive decline in Alzheimer’s disease
Thal, LJ, Grundman, M, Berg, J, Ernstrom, K, Margolin, R, Pfeiffer, E, Weiner, MF, Zamrini, E, & Thomas, RG | Neurology | (2003)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline Drug development
NSAIDs and hypertension
Aisen, Paul S, Schafer, Kimberly, Grundman, Michael, **Thomas, Ronald**, & Thal, Leon J | Archives of internal medicine | (2003)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study
Raskind, Murray A, Peskind, Elaine R, Kanter, Evan D, Petrie, Eric C, Radant, Allen, Thompson, Charles E, Dobie, Dorcas J, Hoff, David, Rein, Rebekah J, Straits-Troster, Kristy, & others | American Journal of Psychiatry | (2003)
Summary: Investigating health impacts in military populations and combat environments
Topics: Biostatistics R Military health
Links: 📄 Article • 📋 Open Access PDF
Self-Management of Age-Related Macular Degeneration and Quality of Life at 6 Months Follow-Up: A Randomized Controlled Trial
Brody, BL, Roch-Levecq, AC, Thomas, RG, Maclean, KK, Kaplan, RM, & Brown, SI | Investigative Ophthalmology \& Visual Science | (2003)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials Longitudinal studies
Links: 📄 Article
Steroid-induced elevation of glucose in Alzheimer’s disease: relationship to gender, apolipoprotein E genotype and cognition
Aisen, PS, Berg, JD, Craft, S, Peskind, ER, Sano, M, Teri, L, Mulnard, RA, Thomas, RG, & Thal, LJ | Psychoneuroendocrinology | (2003)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
2002
A phase I study of AIT-082 in healthy elderly volunteers
Grundman, Michael, Farlow, Martin, Peavy, Guerry, Kim, Hyun T, Capparelli, Edmund, Schultz, Arlan N, Salmon, David P, Ferris, Steven H, Mohs, Richard, **Thomas, Ronald G**, & others | Journal of Molecular Neuroscience | (2002)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
A randomized trial of the effect of a plant-based dietary pattern on additional breast cancer events and survival:: the Women's Healthy Eating and Living (WHEL) Study
Pierce, John P, Faerber, Susan, Wright, Fred A, Rock, Cheryl L, Newman, Vicky, Flatt, Shirley W, Kealey, Sheila, Jones, Vicky E, Caan, Bette J, Gold, Ellen B, & others | Controlled clinical trials | (2002)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials
Links: 📄 Article
Alzheimer’s disease can be accurately diagnosed in very mildly impaired individuals
Salmon, David P, Thomas, RG, Pay, MM, Booth, A, Hofstetter, CR, Thal, LJ, & Katzman, R | Neurology | (2002)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article • 📋 Pre-print PDF
Assessing Alzheimer's disease patients with the Cohen-Mansfield Agitation Inventory: scoring and clinical implications
Weiner, Myron F, Tractenberg, Rochelle E, Jin, Shelia, Gamst, Anthony, **Thomas, Ronald G**, Koss, Elisabeth, & Thal, Leon J | Journal of psychiatric research | (2002)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial
Grundman, Michael, Sencakova, Drahomira, Jack, Clifford R, Petersen, Ronald C, Kim, Hyun T, Schultz, Arlan, Weiner, Myron F, DeCarli, Charles, DeKosky, Steven T, Van Dyck, Christopher, & others | Journal of Molecular Neuroscience | (2002)
Summary: Developing biomarkers and imaging techniques for disease detection
Topics: Biostatistics R Neuroimaging Cognitive decline
Clinical correlates of hippocampal atrophy in patients with mild cognitive impairment
Grundman, M, Kim, HT, Schultz, AN, Thomas, RG, Thal, L, Jack, CR, & Peterson, RC | NEUROBIOLOGY OF AGING | (2002)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Cognitive decline
Links: 📄 Article
Correlates of weight change in Huntington's disease
Hamilton, JM, Corey-Bloom, J, Thomas, RG, Peavy, G, & Jacobson, MW | NEUROLOGY | (2002)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Decline in verbal memory during preclinical Alzheimer's disease: examination of the effect of APOE genotype
Lange, Kelly L, Bondi, Mark W, Salmon, David P, Galasko, Douglas, Delis, Dean C, **Thomas, Ronald G**, & Thal, Leon J | Journal of the International Neuropsychological Society: JINS | (2002)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article • 📋 Pre-print PDF
Indomethacin reduces Helicobacter pylori-induced interleukin-8 (IL-8) production by the gastric epithelial cell line, AGS.
James, MW, Argent, RH, Thomas, R, Hawkey, C, & Atherton, J | GASTROENTEROLOGY | (2002)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Investigating emergent symptomatology as an outcome measure in a behavioral study of Alzheimer's disease
Tractenberg, Rochelle E, Gamst, Anthony, **Thomas, Ronald G**, Patterson, Marian, Schneider, Lon S, & Thal, Leon J | The Journal of neuropsychiatry and clinical neurosciences | (2002)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article • 📋 Open Access PDF
No long-term effect of behavioral treatment on psychotropic drug use for agitation in Alzheimer's disease patients
Weiner, Myron F, Tractenberg, Rochelle E, Sano, Mary, Logsdon, Rebecca, Teri, Linda, Galasko, Douglas, Gamst, Anthony, Thomas, Ron, & Thal, Leon J | Journal of geriatric psychiatry and neurology | (2002)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Drug development
Links: 📄 Article
Psychosocial and Functional Parameters in Patients with Age Related Macular Degeneration and Choroidal Neovascularization with and without Photodynamic Therapy
Goldberg, DE, Roch-Levecq, AC, Maclean, KK, Brody, BL, McGuire, DE, Goldbaum, MH, Thomas, RG, Brown, SI, & Freeman, WR | Investigative Ophthalmology \& Visual Science | (2002)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Drug development
Links: 📄 Article • 📋 Open Access PDF
Results of a multicenter trial of rofecoxib and naproxen in Alzheimer's disease
Aisen, P, Schafer, K, Grundman, M, Farlow, M, Sano, M, Jin, S, Thomas, R, & Thal, L | Neurobiology of Aging | (2002)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
The ADCS clinical trial of melatonin for the sleep disturbance of alzheimer's disease: Case report of an unusual sleep/wake cycle and response to melatonin.
Singer, C, Colling, E, Tractenberg, R, Grundman, M, Gamst, A, Thomas, R, & Thal, L | AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | (2002)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Sleep disorders Clinical trials
Links: 📄 Article
2001
Frequency of behavioral symptoms characterizes agitation in Alzheimer's disease
Tractenberg, Rochelle E, Gamst, Anthony, Weiner, Myron F, Koss, Elisabeth, **Thomas, Ronald G**, Teri, Linda, & Thal, Leon | International journal of geriatric psychiatry | (2001)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Incidence and persistence of psychosis in Alzheimer's disease
Sano, MC, Berg, JD, Thomas, RG, Schneider, LS, Aisen, PS, Mulnard, R, & Thal, LJ | Neurology | (2001)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Metabolic syndrome and ischemic heart disease in elderly men and women
Lindblad, Ulf, Langer, Robert D, Wingard, Deborah L, **Thomas, Ronald G**, & Barrett-Connor, Elizabeth L | American journal of epidemiology | (2001)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
2000
A randomized controlled trial of prednisone in Alzheimer’s disease
Aisen, Paul S, Davis, KL, Berg, JD, Schafer, K, Campbell, K, Thomas, RG, Weiner, MF, Farlow, MR, Sano, M, Grundman, M, & others | Neurology | (2000)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
A randomized controlled trial of prednisone in Alzheimer’s disease
Koch, HJ & Szecsey, A | Neurology | (2000)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
Analysis of longitudinal data in an Alzheimer's disease clinical trial
**Thomas, Ronald G**, Berg, Julie D, Sano, Mary, & Thal, Leon | Statistics in medicine | (2000)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Statistical methods Longitudinal studies
Comparison of the serial position effect in very mild Alzheimer's disease, mild Alzheimer's disease, and amnesia associated with electroconvulsive therapy
Bayley, Peter J, Salmon, David P, Bondi, Mark W, Bui, Barbara K, Olichney, John, Delis, Dean C, **Thomas, Ronald G**, & Thal, Leon J | Journal of the International Neuropsychological Society | (2000)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Drug development
Links: 📄 Article
Description of behaviors emerging in community-dwelling persons with Alzheimer's disease over 12 months
Gamst, A, Thomas, RG, Patterson, M, & Schneider, L | ANNALS OF NEUROLOGY | (2000)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Disorder among Veterans with Substance Abuse
THOMAS, R & MICHAEL, J | THE JOURNaL OF NERvOUs AND MEntal Disease | (2000)
Summary: Investigating health impacts in military populations and combat environments
Topics: Biostatistics R Military health
Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial
Mulnard, Ruth A, Cotman, Carl W, Kawas, Claudia, van Dyck, Christopher H, Sano, Mary, Doody, Rachelle, Koss, Elizabeth, Pfeiffer, Eric, Jin, Shelia, Gamst, Anthony, & others | Jama | (2000)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Drug development
Incidence of and risk factors for hallucinations and delusions in patients with probable AD
Paulsen, Jane S, Salmon, DP, Thal, Leon J, Romero, R, Weisstein--Jenkins, C, Galasko, D, Hofstetter, CR, Thomas, R, Grant, I, & Jeste, DV | Neurology | (2000)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Predicting nursing home placement with change on cognitive measures in Alzheimer's disease
Sano, MC, Berg, JD, Knopman, D, Farlow, MR, & Thomas, RG | Neurology | (2000)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article
Prevalence of symptoms on the CERAD behavior rating scale for dementia in normal elderly subjects and Alzheimer’s disease patients
Tractenberg, Rochelle E, Patterson, Marian, Weiner, Myron F, Teri, Linda, Grundman, Michael, **Thomas, Ronald G**, & Thal, Leon J | The Journal of neuropsychiatry and clinical neurosciences | (2000)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Qualifying change: a method for defining clinically meaningful outcomes of change score computation
Tractenberg, Rochelle E, Jin, Shelia, Patterson, Marian, Schneider, Lon S, Gamst, Anthony, **Thomas, Ronald G**, & Thal, Leon J | Journal of the American Geriatrics Society | (2000)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Statistical methods
Links: 📄 Article
Quantifying behavioral disturbance in Alzheimer's disease patients
Weiner, Myron F, Tractenberg, Rochelle, Teri, Linda, Logsdon, Rebecca, **Thomas, Ronald G**, Gamst, Anthony, & Thal, Leon J | Journal of Psychiatric Research | (2000)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Treatment of agitation in AD: a randomized, placebo-controlled clinical trial
Teri, Linda, Logsdon, RG, Peskind, E, Raskind, M, Weiner, MF, Tractenberg, RE, Foster, NL, Schneider, LS, Sano, M, Whitehouse, P, & others | Neurology | (2000)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials Drug development
Links: 📄 Article • 📋 Open Access PDF
Use of brain MRI volumetric analysis in a mild cognitive impairment trial to delay the diagnosis of Alzheimer’s disease
Grundman, Michael, Sencakova, Drahomira, Jack, CR, Fillit, H, & O’Connell, A | Drug discovery and development for Alzheimer’s disease | (2000)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Neuroimaging Cognitive decline Statistical methods
for the Alzheimer's Disease Cooperative Study: Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial
Mulnard, RA, Cotman, CW, Kawas, C, Van Dyck, CH, Sano, M, Doody, R, Koss, E, Pfeiffer, E, Jin, S, Gamst, A, Grundman, M, Thomas R, & Thal L | JAMA | (2000)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials Drug development
Links: 📄 Article
1999
A normative study of Nelson's (1976) modified version of the Wisconsin Card Sorting Test in healthy older adults
Lineweaver, Tara T, Bondi, Mark W, **Thomas, Ronald G**, & Salmon, David P | The Clinical Neuropsychologist | (1999)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Age-related macular degeneration: a randomized clinical trial of a self-management intervention
Brody, Barbara L, Williams, Rebecca A, **Thomas, Ronald G**, Kaplan, Robert M, Chu, Ray M, & Brown, Stuart I | Annals of Behavioral Medicine | (1999)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials
Links: 📄 Article
Assessment of agitation in Alzheimer's disease: the agitated behavior in dementia scale
Logsdon, Rebecca G, Teri, Linda, Weiner, Myron F, Gibbons, Laura E, Raskind, Murray, Peskind, Elaine, Grundman, > Michael, Koss, Elisabeth, **Thomas, Ronald G**, Thai, Leon J, & others | Journal of the American Geriatrics Society | (1999)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Brief Methodological Reports-Assessment of Agitation in Alzheimer's Disease: The Agitated Behavior in Dementia Scale
Logsdon, Rebecca G, Teri, Linda, Weiner, Myron F, Gibbons, Laura E, Raskind, Murray, Peskind, Elaine, Grundman, Michael, Koss, Elisabeth, **Thomas, Ronald G**, & Thal, Leon J | Journal of the American Geriatrics Society | (1999)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Statistical methods
Links: 📄 Article
Clinical symptoms of dementia with Lewy bodies: Secondary analyses of the Alzheimer's disease cooperative study selegiline and vitamin E clinical trial
Olin, JT, Papka, M, Jin, S, Sano, M, Grundman, M, & Thomas, R | European Neuropsychopharmacology | (1999)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
Ethnic differences in clinical measures among participants in Alzheimer's disease clinical trials
Bell, Karen, Sano, Mary, Jin, Shelia, **Thomas, Ronald**, & Thal, Leon | Neurology | (1999)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
Mini-mental state examination and Mattis Dementia Rating Scale performance differs in Hispanic and non-Hispanic Alzheimer's disease patients
Hohl, Ursula, Grundman, Michael, Salmon, David P, **Thomas, Ronald G**, & Thal, Leon J | Journal of the International Neuropsychological Society | (1999)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Neurochemical markers do not correlate with cognitive decline in the Lewy body variant of Alzheimer disease
Sabbagh, Marwan N, Corey-Bloom, Jody, Tiraboschi, Pietro, **Thomas, Ronald**, Masliah, Eliezer, & Thal, Leon J | Archives of neurology | (1999)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article • 📋 Open Access PDF
Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease.
Bondi, Mark W, Salmon, David P, Galasko, Douglas, **Thomas, Ronald G**, & Thal, Leon J | Psychology and aging | (1999)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Nursing home placement is related to dementia progression: experience from a clinical trial
Knopman, David S, Berg, JD, Thomas, R, Grundman, M, Thal, LJ, Sano, M, & others | Neurology | (1999)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Clinical trials
Links: 📄 Article
The Beneficial Effects of Vitamin E and Selegiline in a Controlled Trial in Alzheimer's Disease Are Independent of the Apolipoprotein E e4 Allele
Galasko, Douglas, Sano, Mary, Berg, Julie, **Thomas, Ronald**, Grundman, Michael, & Thal, Leon | Neurology | (1999)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Weight gain in infants breastfed by mothers who take fluoxetine
Chambers, Christina D, Anderson, Philip O, **Thomas, Ronald G**, Dick, Lyn M, Felix, Robert J, Johnson, Kathleen A, & Jones, Kenneth Lyons | Pediatrics | (1999)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
1998
A comparison of the Cohen-Mansfield agitation inventory with the cerad behavioral rating scale for dementia in community-dwelling persons with Alzheimers disease
Weiner, Myron F, Koss, Elisabeth, Patterson, Marian, Jin, Shelia, Teri, Linda, Thomas, Ron, Thal, Leon J, & Whitehouse, Peter | Journal of psychiatric research | (1998)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Agreement on CDR ratings by committee
Tractenberg, Rochelle, Schafer, Kimberly, Thomas, Ron, & Morris, John C | Controlled Clinical Trials | (1998)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Association of CYP2D microsatellite polymorphism with Lewy body variant of Alzheimer's disease
Tanaka, S, Chen, X, Xia, Y, Kang, DE, Matoh, N, Sundsmo, M, Thomas, RG, Katzman, R, Thal, LJ, Trojanowski, JQ, & others | Neurology | (1998)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article • 📋 Open Access PDF
Cognitive and functional abilities in severely demented Alzheimer's patients
Peavy, GM, Salmon, DP, & Thomas, RG | CLINICAL NEUROPSYCHOLOGIST | (1998)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article
Design and baseline characteristics of the veterans affairs non-Q-wave infarction strategies in-hospital (VANQWISH) trial
Ferry, David R, O’Rourke, Robert A, Blaustein, Alvin S, Crawford, Michael H, Deedwania, Prakash C, Carson, Peter E, Zoble, Robert G, Pepine, Carl J, **Thomas, Ronald G**, Chow, Bruce K, & others | Journal of the American College of Cardiology | (1998)
Summary: Investigating health impacts in military populations and combat environments
Topics: Biostatistics R Military health
Dynamic measurement scale development for clinical trials in targeted populations
Jin, Shelia, **Thomas, Ronald G**, Galasko, Douglas, & Thal, Leon J | Controlled Clinical Trials | (1998)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials Epidemiology
Links: 📄 Article • 📋 Open Access PDF
High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype
Galasko, D, Chang, L, Motter, R, Clark, CM, Kaye, Jeffrey, Knopman, D, Thomas, R, Kholodenko, D, Schenk, D, Lieberburg, I, & others | Archives of neurology | (1998)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Interaction of apolipoprotein E 4 with other genetic and non-genetic risk factors in late onset Alzheimer disease: problems facing the investigator
Katzman, R, Kang, D, & Thomas, R | Neurochemical research | (1998)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Measuring cognitive progression in Alzheimer's disease
Berg, Julie D, **Thomas, Ronald G**, Thal, Leon J, & Sano, Mary | Controlled Clinical Trials | (1998)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Power calculation for randomized start design
Kean, Yin M, **Thomas, Ronald G**, & Thal, Leon J | Controlled Clinical Trials | (1998)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Clinical trials
Links: 📄 Article
Practice effects on the modified Wisconsin card sorting test in normally aging adults
Lineweaver, TT, Bondi, MW, & Thomas, RG | Archives of Clinical Neuropsychology | (1998)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
The electrocardiographic exercise test in a population with reduced workup bias: diagnostic performance, computerized interpretation, and multivariable prediction
Froelicher, Victor F, Lehmann, Kenneth G, **Thomas, Ronald**, Goldman, Steven, Morrison, Douglas, Edson, Robert, Lavori, Philip, Myers, Jonathan, Dennis, Charles, Shabetai, Ralph, & others | Annals of internal medicine | (1998)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Epidemiology
Links: 📄 Article
The psychosocial impact of macular degeneration
Williams, Rebecca A, Brody, Barbara L, **Thomas, Ronald G**, Kaplan, Robert M, & Brown, Stuart I | Archives of ophthalmology | (1998)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
The relationship between Nursing home placement and measures of change in Alzheimer's disease
Knopman, David, Sano, Mary, Berg, Julie, & **Thomas, Ronald** | Neurology | (1998)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Use of the world wide web in data dissemination to central review committees
Schafer, Kimberly A, Welty, Greg, & **Thomas, Ronald G** | Controlled Clinical Trials | (1998)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Utility of psychophysiological measurement in the diagnosis of posttraumatic stress disorder: results from a Department of Veterans Affairs Cooperative Study.
Keane, Terence M, Kolb, Lawrence C, Kaloupek, Danny G, Orr, Scott P, Blanchard, Edward B, **Thomas, Ronald G**, Hsieh, Frank Y, & Lavori, Philip W | Journal of consulting and clinical psychology | (1998)
Summary: Investigating health impacts in military populations and combat environments
Topics: Biostatistics R Military health
1997
53 Power comparisons among different number of categories under ordered polytomous logistic regression model
Jeong, Jong-Hyeon, Klauber, Melville R, **Thomas, Ronald G**, Grundman, Michael, & Thal, Leon J | Controlled Clinical Trials | (1997)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
A Multicenter Evaluation of New Treatment Efficacy
Whitehouse, Peter J, Schmitt, HFrederick A, Sano, Mary, & **Thomas, Ronald G** | Alzheimer Disease and Associated Disorders | (1997)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Drug development
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease
Sano, Mary, Ernesto, Christopher, **Thomas, Ronald G**, Klauber, Melville R, Schafer, Kimberly, Grundman, Michael, Woodbury, Peter, Growdon, John, Cotman, Carl W, Pfeiffer, Eric, & others | New England Journal of Medicine | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Drug development
Links: 📄 Article • 📋 Open Access PDF
A longitudinal study of behavioral pathology across five levels of dementia severity in Alzheimer's disease: The CERAD Behavior Rating Scale for Dementia.
Patterson, Marian B, Mack, James L, Mackell, Joan A, **Thomas, Ronald**, Tariot, Pierre, Weiner, Myron, & Whitehouse, Peter J | Alzheimer disease and associated disorders | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Longitudinal studies
Links: 📄 Article
Alpha-tocopherol and Alzheimer's disease
Sano, Mary, **Thomas, Ronald G**, & Thal, Leon J | The New England Journal of Medicine | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
An inventory to assess activities of daily living for clinical trials in Alzheimer's disease.
Galasko, Douglas, Bennett, David, Sano, Mary, Ernesto, Chris, **Thomas, Ronald**, Grundman, Michael, & Ferris, Steven | Alzheimer disease and associated disorders | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
ApoE genotype influences the CSF level of A $\\beta$ 42 in Alzheimer's disease
Seubert, PA, Motter, RN, Schenk, DB, Lieberburg, IM, Kholodenko, D, Galasko, D, Thomas, R, Chang, L, Miller, B, Clark, C, & others | Neurology | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Assessing patterns of agitation in Alzheimer's disease patients with the Cohen-Mansfield Agitation Inventory. The Alzheimer's Disease Cooperative Study.
Koss, Elisabeth, Weiner, Myron, Ernesto, Christopher, Cohen-Mansfield, Jiska, Ferris, Steven H, Grundman, Michael, Schafer, Kimberly, Sano, Mary, Thal, Leon J, **Thomas, Ronald**, & others | Alzheimer Disease and Associated Disorders | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
CSF levels of A beta 432 and tau as aids to diagnosing Alzheimer's disease
Galasko, D, Seubert, P, Motter, R, Schenk, D, Kholodenko, D, Lieberburg, I, Chang, L, Miller, B, Clark, C, Kaye, J, & others | Neurology | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article • 📋 Open Access PDF
Defective Neurite Extension Is Caused by a Mutation in Amyloid /A4 (A ) Protein Precursor Found in Familial Alzheimer's Disease
Roch, J-M, Sundsmo, M, Otero, D, Sisodia, S, Thomas, R, & Saitoh, T | JOURNAL OF NEUROBIOLOGY | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Defective neurite extension is caused by a mutation in amyloid beta protein precursor found in familial Alzheimer's disease
Li, Hai Ling, Roch, Jean-Marc, Sundsmo, Mary, Otero, Deborah, Sisodia, Sangram, **Thomas, Ronald**, & Saitoh, Tsunao | Journal of neurobiology | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
Diagnostic accuracy of dementia with Lewy bodies: A prospective evaluation
Hohl, U, CoreyBloom, J, Hansen, LA, Thomas, RG, & Thal, LJ | Neurology | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
Effects of Selegiline and alpha-Tocopherol on cognitive and functional outcome measures in moderately impaired patients with Alzheimer's disease
Sano, M, Ernesto, C, Thomas, RG, Klauber, MR, Schafer, K, Grundman, M, Woodbury, P, Growdon, J, Cotman, CW, Pfeiffer, E, & others | Neurology | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article
Effects of apolipoprotein E on dementia and aging in the Shanghai Survey of Dementia
Katzman, R, Zhang, M-Y, Chen, PJ, Gu, N, Jiang, S, Saitoh, T, Chen, X, Klauber, M, Thomas, RG, Liu, WT, & others | Neurology | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
Estrogen, apolipoprotein E, and dementia
Barrett-Connor, Elizabeth & **Thomas, Ronald G** | Journal of women's health | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R
Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), and apolipoprotein E receptor, with late-onset Alzheimer's disease
Kang, DE, Saitoh, T, Chen, X, Xia, Y, Masliah, E, Hansen, LA, Thomas, RG, Thal, LJ, & Katzman, R | Neurology | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
P23 use of the world wide web for clinical monitoring in multicenter clinical trials
Schafer, Kimberly, **Thomas, Ronald G**, Welty, Greg, Berry, Angela Lambert, & Schittini, Mario | Controlled Clinical Trials | (1997)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials
Links: 📄 Article
Quality of life among elderly adults with macular degeneration
Williams, RA, Brody, BL, Kaplan, RM, Thomas, RG, & Brown, SI | INVESTIGATIVE OPHTHALMOLOGY \& VISUAL SCIENCE | (1997)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Tacrine and nursing home placement
Thal, Leon J, **Thomas, Ronald G**, & Sano, Mary | Neurology | (1997)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
The Spanish Instrument Protocol: Design and implementation of a study to evaluate treatment efficacy instruments for Spanish-speaking patients with Alzheimer's disease.
Sano, M, Mackell, JA, Ponton, M, Ferreira, P, Wilson, J, Pawluczyk, S, Pfeiffer, E, Thomas, RG, Jin, S, Schafer, K, & others | Alzheimer disease and associated disorders | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Drug development
Links: 📄 Article
Validity and reliability of the Alzheimer’s Disease Cooperative Study-Clinical global impression of change (ADCS-CGIC)
Schneider, Lon S, Olin, Jason T, Doody, Rachelle S, Clark, Christopher M, Morris, John C, Reisberg, Barry, Ferris, Steven H, Schmitt, Frederick A, Grundman, Michael, & **Thomas, Ronald G** | Alzheimer Disease | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
for the members of the Alzheimer’s Disease Cooperative Study
Sano, M, Ernesto, C, Thomas, RG, Klauber, MR, Schafer, K, Grundman, M, Woodbury, P, Growden, J, Cotnman, C, Pfeiffer, E, & others | A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. N Engl J Med | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
the Alzheimer's Disease Cooperative Study. Validity and reliability of the Alzheimer's disease cooperative study-clinical global impression of change
Schneider, LS, Olin, JT, Doody, RS, Clark, CM, Morris, JC, Reisberg, B, Schmitt, FA, Grundman, M, Thomas, RG, & Ferris, SH | Alzheimer Dis Assoc Disord | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
Links: 📄 Article
the Alzheimer’s Disease Cooperative Study. An inventory to assess activities of daily living for clinical trials in Alzheimer’s disease
Galasko, D, Bennett, D, Sano, M, Ernesto, C, Thomas, R, Grundman, M, & Ferris, S | Alzheimer Dis Assoc Disord | (1997)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
1996
A32 computer-aided clinical monitoring: Results of a controlled experiment
**Thomas, Ronald G**, Schafer, Kimberly, Woodbury, Peter, White, Beverly, Mackell, Joan, Lambert, Angie, & Scattini, Mario | Controlled Clinical Trials | (1996)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
A34 Clinical monitoring of rating scales in multicenter clinical trials
Schafer, Kimberly, Ernesto, Christopher, Sano, Mary, Mackell, Joan, **Thomas, Ronald**, & Morris, John C | Controlled Clinical Trials | (1996)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials
Links: 📄 Article • 📋 Open Access PDF
ApoE and CYP2D6 polymorphism with and without parkinsonism-dementia complex in the people of Chamorro, Guam
Chen, X, Xia, Y, Gresham, LS, Molgaard, CA, Thomas, RG, Galasko, D, Wiederholt, WC, & Saitoh, T | Neurology | (1996)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R
Links: 📄 Article
Apolipoprotein-epsilon4 and head trauma: Synergistic or additive risks?
Katzman, R, Galasko, DR, Saitoh, T, Chen, X, Pay, MM, Booth, A, & Thomas, RG | Neurology | (1996)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Development of a pool of items to assess activities of daily living in clinical trials for Alzheimer's disease
Galasko, D, Bennett, D, Ernesto, C, Thomas, R, & Sano, M | Neurology | (1996)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
Evaluation of efficacy measures in clinical trials for Alzheimer's disease: Does psychometric test performance predict clinically relevant outcomes?
Sano, M, Growdon, J, Thomas, R, Ernesto, C, Schafer, K, Woodbury, P, Grundman, M, & Thal, L | Neurology | (1996)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Clinical trials
Links: 📄 Article
Familial melanoma and pancreatic cancer
Wright, Fred A & **Thomas, Ronald G** | The New England journal of medicine | (1996)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
P63 Informed consent issues when including genetic testing in clinical trials
Schafer, Kimberly, **Thomas, Ronald**, Galasko, Douglas, Morris, John C, Whitehouse, Peter, Bochenek, Jacqueline, & Thal, Leon | Controlled Clinical Trials | (1996)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials
Links: 📄 Article
Rate of dementia of the Alzheimer type (DAT) in subjects with mild cognitive impairment
Grundman, Michael, Petersen, Ronald C, Morris, JC, Ferris, S, Sano, Mary, Farlow, Martin R, Doody, Rachel S, Galasko, D, Ernesto, C, Thomas, RG, & others | Neurology | (1996)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline
Links: 📄 Article
Rationale and design of a multicenter study of selegiline and alpha-tocopherol in the treatment of Alzheimer disease using novel clinical outcomes. Alzheimer's Disease Cooperative Study.
Sano, Mary, Ernesto, Christopher, Klauber, Melville R, Schafer, Kimberly, Woodbury, Peter, **Thomas, Ronald**, Grundman, Michael, Growdon, John, & Thal, Leon J | Alzheimer disease and associated disorders | (1996)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Drug development
Links: 📄 Article • 📋 Open Access PDF
Substance-dependent inpatients who accept smoking treatment
Seidner, Andrea L, Burling, Thomas A, Gaither, David E, & **Thomas, Ronald G** | Journal of Substance Abuse | (1996)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Drug development
Validity and reliability of the Alzheimers disease cooperative study-clinical global impression of change (ADCS-CGIC)
Schneider, Lon S, Olin, Jason T, Doody, Rachelle S, Clark, Christopher M, Morris, John C, Reisberg, Barry, Ferris, Steven H, Schmitt, Frederick A, Grundman, Michael, & **Thomas, Ronald G** | Alzheimer Disease Springer | (1996)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease
1995
Prospective study of hospitalization for asthma: a preliminary risk factor model
Li, Dominic, German, Donald, Lulla, Sulochina, **Thomas, Ronald G**, & Wilson, Sandra R | American journal of respiratory and critical care medicine | (1995)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
The Spanish Instrument Protocol: a Study to Evaluate Treatment Efficacy Instruments for Spanish-Speaking Patients with Alzheimer's Disease
Thomas, RG, Jin, S, Schafer, K, Schittini, M, Grundman, M, & Ferris, SH | Alzheimer Disease and Associated Disorders | (1995)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Drug development
1994
Application of neural networks to the classification of giant cell arteritis
Astion, Michael L, Wener, Mark H, **Thomas, Ronald G**, Hunder, Gene G, & Bloch, Daniel A | Arthritis \& Rheumatism: Official Journal of the American College of Rheumatology | (1994)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Drug and alcohol abuse inpatients' attitudes about smoking cessation
Irving, Lori M, Seidner, Andrea L, Burling, Thomas A, **Thomas, Ronald G**, & Brenner, Gail F | Journal of Substance Abuse | (1994)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Drug development
Links: 📄 Article
Zweibaryonensysteme mit Strangeness und die Antikaon-Deuteron Streuung
Thomas, Ralf | (1994)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
1993
A controlled trial of two forms of self-management education for adults with asthma
Wilson, Sandra R, Scamagas, Peter, German, Donald F, Hughes, Gary W, Lulla, Sulochina, Coss, Stamatiki, Chardon, Luis, **Thomas, Ronald G**, Starr-Schneidkraut, Norma, Stancavage, Frances B, & others | The American journal of medicine | (1993)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R
Algorithm AS 280: the power function for Fisher's exact test
Conlon, Michael & **Thomas, Ronald G** | Journal of the Royal Statistical Society. Series C (Applied Statistics) | (1993)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Overtraining in neural networks that interpret clinical data
Astion, ML, Wener, MH, Thomas, RG, Hunder, GG, & Bloch, DA | Clinical chemistry | (1993)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Prediction of cardiovascular death in men undergoing noninvasive evaluation for coronary artery disease
Morrow, Kiernan, Morris, Charles K, Froelicher, Victor F, Hideg, Alisa, Hunter, Dodie, Johnson, Eileen, Kawaguchi, Takeo, Lehmann, Kenneth, Ribisl, Paul M, **Thomas, Ronald**, & others | Annals of Internal Medicine | (1993)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Trimethoprim-sulfamethoxazole prophylaxis in granulocytopenic patients with acute leukemia: evaluation of serum antibiotic levels in a randomized, double-blind, placebo-controlled Department of Veterans Affairs Cooperative Study
Ward, TT, Thomas, RG, Fye, CL, Arbeit, R, Coltman Jr, CA, Craig, W, Dana, BW, Finegold, SM, Lentino, J, Penn, RL, & others | Clinical infectious diseases | (1993)
Summary: Investigating health impacts in military populations and combat environments
Topics: Biostatistics R Clinical trials Military health
1992
An algorithm for the rapid evaluation of the power function for Fisher's Exact Test
**Thomas, Ronald G** & Conlon, Michael | Journal of statistical computation and simulation | (1992)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Calculation of observables in the pion-deuteron system. Berechnung von Observablen im Pion Deuteron-System
Beuschel, T, Feldkeller, B, Fuchs, M, Huber, MG, Metsch, BC, & Thomas, R | Verhandlungen der Deutschen Physikalischen Gesellschaft;(Germany) | (1992)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Concave hymenal variations in suspected child sexual abuse victims
Kerns, David L, Ritter, Mary L, & **Thomas, Ronald G** | Pediatrics | (1992)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
PROGRESSION OF FUNCTIONAL DISABILITY IN RHEUMATOID-ARTHRITIS
RAYNAULD, JP, THOMAS, RG, & BLOCH, DA | ARTHRITIS AND RHEUMATISM | (1992)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Sample size determination based on Fisher's exact test for use in 2 x 2 comparative trials with low event rates
**Thomas, Ronald G** & Conlon, Michael | Controlled clinical trials | (1992)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R
Two-baryon systems with strangeness S=-1 and S=-2
Fuchs, M, Huber, MG, Metsch, BC, & Thomas, R | Verhandlungen der Deutschen Physikalischen Gesellschaft | (1992)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
1991
An analysis of methods of communication in clinical trials
Sheridan, Lenore & **Thomas, Ronald G** | Controlled Clinical Trials | (1991)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Clinical trials Statistical methods
Integration of statutory provisions of NEPA, RCRA, and CERCLA at the Savannah River site. Revision 1
Gordon, DE, Thomas, R, Shedrow, CB, & Wilson, MP | (1991)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
1990
A new confidence interval for the difference of two binomial proportions
Conlon, Michael & **Thomas, Ronald G** | Computational Statistics \& Data Analysis | (1990)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Data monitoring through stochastic curtailing when the outcome proportions are small: An exact approach
**Thomas, Ronald G** | Controlled Clinical Trials | (1990)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Development of an active target for scattering of neutral baryons
Thomas, R, Empl, E, Kilian, K, Oelert, W, Roderburg, E, Sefzick, T, Sehl, G, Steinkamp, O, & Ziolkowski, M | Verhandlungen der Deutschen Physikalischen Gesellschaft | (1990)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
Test measurements of an asymmetric induction drift chamber with flash ADC's
Decker, G, Kilian, K, Lippert, C, Oelert, W, Roderburg, E, Sefzick, T, Sehl, G, Steinkamp, O, Thomas, R, Ziolkowski, M, & others | Verhandlungen der Deutschen Physikalischen Gesellschaft | (1990)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
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Tyrell, Doris, Cline, Dorothy R, & **Thomas, Ronald G** | Controlled Clinical Trials | (1990)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
1989
Effect of zinc supplementation on the development of cardiovascular disease in the elderly
Hale, William E, May, Franklin E, **Thomas, Ronald G**, Moore, Mary T, & Stewart, Ronald B | Journal of Nutrition for the Elderly | (1989)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Exact sample size calculations for 2x2 comparative trials when the outcome proportions are small
**Thomas, Ronald G** | Controlled Clinical Trials | (1989)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
Risk factors, time course and treatment effect for restenosis after successful percutaneous transluminal coronary angioplasty of chronic total occlusion
Ellis, Stephen G, Shaw, Richard E, Gershony, Gary, **Thomas, Ronald**, Roubin, Gary S, Douglas Jr, John S, Topol, Eric J, Startzer, Simon H, Myler, Richard K, & King III, Spencer B | The American journal of cardiology | (1989)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R Drug development
Links: 📄 Article
1988
Angiographic and clinical predictors of acute closure after native vessel coronary angioplasty.
Ellis, SG, Roubin, GS, King 3rd, SB, Douglas Jr, JS, Weintraub, WS, Thomas, RG, & Cox, WR | Circulation | (1988)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
FORMS INVENTORY SYSTEM FOR A COMPLEX CLINICAL-TRIAL
MELLEN, BG, THOMAS, RG, & CASTANO, D | CONTROLLED CLINICAL TRIALS | (1988)
Summary: Evaluating therapeutic interventions through rigorous clinical trials
Topics: Biostatistics R
Links: 📄 Article
Influence of balloon size on initial success, acute complications, and restenosis after percutaneous transluminal coronary angioplasty. A prospective randomized study.
Roubin, Gary S, Douglas Jr, John S, King 3rd, SB, Lin, SF, Hutchison, Nancy, Thomas, RG, & Gruentzig, AR | Circulation | (1988)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Clinical trials
Links: 📄 Article
1987
A comparison of single lesion dilatation in single vessel and multivessel disease
Mufson, LGAR, Roubin, GS, Black, A, & Thomas, RG | Circulation | (1987)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
Effects of behavioral self-management on oral hygiene adherence among orthodontic patients
McGlynn, F Dudley, LeCompte, E Joseph, **Thomas, Ronald G**, Courts, Frank J, & Melamed, Barbara G | American Journal of Orthodontics and Dentofacial Orthopedics | (1987)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Impact of air filtration on nosocomial Aspergillus infections: unique risk of bone marrow transplant recipients
Sherertz, Robert J, Belani, Anusha, Kramer, Barnett S, Elfenbein, Gerald J, Weiner, Roy S, Sullivan, Marsha L, **Thomas, Ronald G**, & Samsa, Gregory P | The American journal of medicine | (1987)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
Impact of air filtration on nosocomial aspergillus infections
Shcrertz, RJ, Belani, A, Kramer, BS, & others | Am J Med | (1987)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
Is there dependence between sites for continued success or restenosis after successful multisite coronary angioplasty
Thomas, RG, Black, A, Lin, S, Chin, H, & Weintraub, WS | Circulation | (1987)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
PROGNOSIS AFTER MULTIPLE VESSEL ANGIOPLASTY (PTCA) IN PATIENTS WITH CORONARY-ARTERY DISEASE
Roubin, GS, Sutor, C, Lembo, NJ, Hoffmeister, J, Thomas, RG, Douglas, JS, & King, SB | Circulation | (1987)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
1986
Alzheimer's disease: a correlational analysis of the Blessed Information-Memory-Concentration test and the Mini-Mental State Exam
Thal, Leon J, Grundman, Michael, & Golden, Robert | Neurology | (1986)
Summary: Advancing understanding of neurodegenerative diseases through clinical research
Topics: Biostatistics R Alzheimer's disease Cognitive decline Statistical methods
1985
1984
Changes in shoulder and leg strength in athletes wearing mandibular orthopedic repositioning appliances
Schubert, Mark M, Guttu, Ronald L, Hunter, Letha H, Hall, Richard, & **Thomas, Ronald** | The Journal of the American Dental Association | (1984)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article
1983
Early prediction of the adult respiratory distress syndrome by a simple scoring method
Pepe, Paul E, **Thomas, Ronald G**, Stager, Marie Anne, Hudson, Leonard D, & Carrico, C James | Annals of emergency medicine | (1983)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Statistical methods
Effects of concomitant development on reproduction of Meloidogyne incognita and Rotylenchulus reniformis on sweet potato
**Thomas, Ronald J** & Clark, Christopher A | Journal of Nematology | (1983)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article • 📋 Open Access PDF
Population dynamics of Meloidogyne incognita and Rotylenchulus reniformis alone and in combination, and their effects on sweet potato
**Thomas, Ronald J** & Clark, Christopher A | Journal of Nematology | (1983)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R Epidemiology
Links: 📄 Article • 📋 Open Access PDF
THE EFFECT OF MANDIBULAR ORTHOPEDIC REPOSITIONING APPLIANCES ON BODY STRENGTH
Schubert, M, Guttu, R, Hunter, L, Hall, R, & Thomas, R | JOURNAL OF DENTAL RESEARCH | (1983)
Summary: Contributing to evidence-based medicine and biostatistical research
Topics: Biostatistics R
Links: 📄 Article